Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the United States military

The importance of timing of exposure measurement

Christine M. Arcari, Charlotte A. Gaydos, E. Javier Nieto, Margot Krauss, Kenrad E. Nelson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background. Several investigators have found that Chlamydia pneumoniae and cytomegalovirus infections may be risk factors for coronary heart disease. However, the data remain controversial. To address this hypothesis, data and specimens were collected from a well-established prospective cohort of active-duty personnel from the US military. Methods. A nested case-control study was conducted with 300 case patients and 300 matched control subjects. Case patients were men (age, 30-50 years) with a medically documented, first-time hospitalization for acute myocardial infarction (MI) and from whom a serum specimen had been drawn ≥1 year before the time of the acute MI. Population-based control subjects were chosen from the same cohort and were individually matched by age, race, and time of specimen collection. Evidence of past infections with C. pneumoniae and cytomegalovirus were measured by microimmunofluorescence assay and enzyme-linked immunosorbent assay, respectively. Results. Significant risk was associated with high titer (≥1:64) to C. pneumoniae immunoglobulin A (IgA) (adjusted relative risk [RRadj], 1.67; 95% confidence interval [CI], 1.04-2.70). This increased risk was greatest when specimens were collected 1-5 years before the event (RRadj, 2.11; 95% CI, 1.06-4.21). High titer (≥1:256) to C. pneumoniae immunoglobulin G (IgG) was also associated with an elevated risk (RRadj, 1.74; 95% CI, 0.90-3.34) after full adjustment for cardiovascular risk factors, whereas no independent risk for acute MI was associated with cytomegalovirus IgG seropositivity. Conclusions. This study demonstrates a significant association between high titers to C. pneumoniae IgG and IgA and acute MI in a cohort of young men and suggests that recent or chronic active infections could be associated with an increased risk for MI.

Original languageEnglish (US)
Pages (from-to)1123-1130
Number of pages8
JournalClinical Infectious Diseases
Volume40
Issue number8
DOIs
StatePublished - Apr 15 2005
Externally publishedYes

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Chlamydophila pneumoniae
Myocardial Infarction
Immunoglobulin G
Confidence Intervals
Cytomegalovirus
Immunoglobulin A
Specimen Handling
Chlamydia Infections
Population Control
Military Personnel
Cytomegalovirus Infections
Infection
Coronary Disease
Case-Control Studies
Hospitalization
Enzyme-Linked Immunosorbent Assay
Research Personnel
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the United States military : The importance of timing of exposure measurement. / Arcari, Christine M.; Gaydos, Charlotte A.; Nieto, E. Javier; Krauss, Margot; Nelson, Kenrad E.

In: Clinical Infectious Diseases, Vol. 40, No. 8, 15.04.2005, p. 1123-1130.

Research output: Contribution to journalArticle

Arcari, Christine M. ; Gaydos, Charlotte A. ; Nieto, E. Javier ; Krauss, Margot ; Nelson, Kenrad E. / Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the United States military : The importance of timing of exposure measurement. In: Clinical Infectious Diseases. 2005 ; Vol. 40, No. 8. pp. 1123-1130.
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abstract = "Background. Several investigators have found that Chlamydia pneumoniae and cytomegalovirus infections may be risk factors for coronary heart disease. However, the data remain controversial. To address this hypothesis, data and specimens were collected from a well-established prospective cohort of active-duty personnel from the US military. Methods. A nested case-control study was conducted with 300 case patients and 300 matched control subjects. Case patients were men (age, 30-50 years) with a medically documented, first-time hospitalization for acute myocardial infarction (MI) and from whom a serum specimen had been drawn ≥1 year before the time of the acute MI. Population-based control subjects were chosen from the same cohort and were individually matched by age, race, and time of specimen collection. Evidence of past infections with C. pneumoniae and cytomegalovirus were measured by microimmunofluorescence assay and enzyme-linked immunosorbent assay, respectively. Results. Significant risk was associated with high titer (≥1:64) to C. pneumoniae immunoglobulin A (IgA) (adjusted relative risk [RRadj], 1.67; 95{\%} confidence interval [CI], 1.04-2.70). This increased risk was greatest when specimens were collected 1-5 years before the event (RRadj, 2.11; 95{\%} CI, 1.06-4.21). High titer (≥1:256) to C. pneumoniae immunoglobulin G (IgG) was also associated with an elevated risk (RRadj, 1.74; 95{\%} CI, 0.90-3.34) after full adjustment for cardiovascular risk factors, whereas no independent risk for acute MI was associated with cytomegalovirus IgG seropositivity. Conclusions. This study demonstrates a significant association between high titers to C. pneumoniae IgG and IgA and acute MI in a cohort of young men and suggests that recent or chronic active infections could be associated with an increased risk for MI.",
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AU - Nelson, Kenrad E.

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