Association between endogenous sex steroid hormones and inflammatory biomarkers in US men

K. K. Tsilidis, S. Rohrmann, K. A. Mcglynn, S. J. Nyante, David Lopez, G. Bradwin, M. Feinleib, C. E. Joshu, N. Kanarek, W. G. Nelson, E. Selvin, E. A. Platz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Sex steroid hormones and inflammatory biomarkers are both associated with the development and progression of chronic diseases, but their interrelationship is relatively uncharacterized. We examined the association of sex hormones and sex hormone-binding globulin (SHBG) with biomarkers of inflammation, C-reactive protein (CRP) and white blood cell (WBC) count. The study included data from 809 adult men in the National Health and Nutrition Examination Survey 1999-2004. Geometric means and 95% confidence intervals were estimated separately for CRP and WBC concentrations by sex steroid hormones and SHBG using weighted linear regression models. Higher concentrations of total (slope per one quintile in concentration, -0.18; p-trend, 0.001) and calculated free (slope, -0.13; p-trend, 0.03) testosterone were statistically significantly associated with lower concentrations of CRP, but not with WBC count. Men in the bottom quintile of total testosterone (≤3.3 ng/mL), who might be considered to have clinically low testosterone, were more likely to have elevated CRP (≥3 mg/L) compared with men in the top four quintiles (OR, 1.61; 95% CI, 1.00-2.61). Total and calculated free estradiol (E2) were positively associated with both CRP (Total E2: slope, 0.14; p-trend, <0.001; Free E2: slope, 0.15; p-trend, <0.001) and WBC (Total E2: slope, 0.02; p-trend, 0.08; Free E2: slope, 0.02; p-trend, 0.02) concentrations. SHBG concentrations were inversely associated with WBC count (slope, -0.03; p-trend, 0.04), but not with CRP. These cross-sectional findings are consistent with the hypothesis that higher androgen and lower oestrogen concentrations may have an anti-inflammatory effect in men.

Original languageEnglish (US)
Pages (from-to)919-928
Number of pages10
JournalAndrology
Volume1
Issue number6
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

Fingerprint

Gonadal Steroid Hormones
C-Reactive Protein
Biomarkers
Sex Hormone-Binding Globulin
Leukocyte Count
Testosterone
Linear Models
Leukocytes
Nutrition Surveys
Androgens
Estradiol
Estrogens
Chronic Disease
Anti-Inflammatory Agents
Confidence Intervals
Inflammation

Keywords

  • C-reactive protein
  • Cross-sectional study
  • Estradiol
  • Testosterone
  • White blood cell

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

Cite this

Tsilidis, K. K., Rohrmann, S., Mcglynn, K. A., Nyante, S. J., Lopez, D., Bradwin, G., ... Platz, E. A. (2013). Association between endogenous sex steroid hormones and inflammatory biomarkers in US men. Andrology, 1(6), 919-928. https://doi.org/10.1111/j.2047-2927.2013.00129.x

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men. / Tsilidis, K. K.; Rohrmann, S.; Mcglynn, K. A.; Nyante, S. J.; Lopez, David; Bradwin, G.; Feinleib, M.; Joshu, C. E.; Kanarek, N.; Nelson, W. G.; Selvin, E.; Platz, E. A.

In: Andrology, Vol. 1, No. 6, 01.11.2013, p. 919-928.

Research output: Contribution to journalArticle

Tsilidis, KK, Rohrmann, S, Mcglynn, KA, Nyante, SJ, Lopez, D, Bradwin, G, Feinleib, M, Joshu, CE, Kanarek, N, Nelson, WG, Selvin, E & Platz, EA 2013, 'Association between endogenous sex steroid hormones and inflammatory biomarkers in US men', Andrology, vol. 1, no. 6, pp. 919-928. https://doi.org/10.1111/j.2047-2927.2013.00129.x
Tsilidis, K. K. ; Rohrmann, S. ; Mcglynn, K. A. ; Nyante, S. J. ; Lopez, David ; Bradwin, G. ; Feinleib, M. ; Joshu, C. E. ; Kanarek, N. ; Nelson, W. G. ; Selvin, E. ; Platz, E. A. / Association between endogenous sex steroid hormones and inflammatory biomarkers in US men. In: Andrology. 2013 ; Vol. 1, No. 6. pp. 919-928.
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