Association between endogenous sex steroid hormones and insulin-like growth factor proteins in US men

Stefania I. Papatheodorou, Sabine Rohrmann, David Lopez, Gary Bradwin, Corinne E. Joshu, Norma Kanarek, William G. Nelson, Nader Rifai, Elizabeth A. Platz, Konstantinos K. Tsilidis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Sex steroid hormone concentrations and insulin-like growth factor (IGF) proteins have been independently associated with risk of cancer, chronic diseases, and mortality. However, studies that evaluated the inter-relation between the sex hormones and IGF pathways have provided mixed results. We examined the association between endogenous sex hormones and sex hormone-binding globulin (SHBG) with IGF-1 and IGF-binding protein 3 (IGFBP-3) in a population-based sample of US men. Methods: Data from 1,135 men aged 20 years or older participating in the third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Weighted linear regression was used to estimate geometric means and 95 % confidence intervals for IGF-1 and IGFBP-3 concentrations by sex steroid hormones and SHBG after adjusting for age, race/ethnicity, body mass index, waist circumference, alcohol consumption, cigarette smoking, physical activity, diabetes, and mutually adjusting for other sex hormones and SHBG. Results: No significant association was observed between sex steroid hormones, SHBG, and IGF-1 concentrations. Total estradiol (% difference in Q5 - Q1 geometric means -9.7 %; P-trend 0.05) and SHBG (% difference -7.3 %; P-trend 0.02) were modestly inversely associated with IGFBP-3. Total testosterone was modestly inversely associated with IGFBP-3 (% difference -6.2 %; P-trend 0.01), but this association disappeared after adjustment for total estradiol and SHBG (% difference 2.6 %; P-trend 0.23). Androstanediol glucuronide was not associated with IGFBP-3. Conclusions: These findings suggest that there may be inter-relationships between circulating total estradiol, SHBG, and IGFBP-3 concentrations. Future research may consider these inter-relationships when evaluating potential joint effects of the sex hormones and IGF pathways.

Original languageEnglish (US)
Pages (from-to)353-363
Number of pages11
JournalCancer Causes and Control
Volume25
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Sex Hormone-Binding Globulin
Gonadal Steroid Hormones
Somatomedins
Insulin-Like Growth Factor Binding Protein 3
Proteins
Estradiol
Nutrition Surveys
Glucuronides
Waist Circumference
Alcohol Drinking
Testosterone
Linear Models
Body Mass Index
Chronic Disease
Smoking
Confidence Intervals
Exercise
Mortality
Population

Keywords

  • Estradiol
  • Insulin growth factor-1 (IGF-1)
  • Insulin growth factor-binding protein 3 (IGFBP-3)
  • Sex hormone-binding globulin (SHBG)
  • Testosterone

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Papatheodorou, S. I., Rohrmann, S., Lopez, D., Bradwin, G., Joshu, C. E., Kanarek, N., ... Tsilidis, K. K. (2014). Association between endogenous sex steroid hormones and insulin-like growth factor proteins in US men. Cancer Causes and Control, 25(3), 353-363. https://doi.org/10.1007/s10552-013-0336-4

Association between endogenous sex steroid hormones and insulin-like growth factor proteins in US men. / Papatheodorou, Stefania I.; Rohrmann, Sabine; Lopez, David; Bradwin, Gary; Joshu, Corinne E.; Kanarek, Norma; Nelson, William G.; Rifai, Nader; Platz, Elizabeth A.; Tsilidis, Konstantinos K.

In: Cancer Causes and Control, Vol. 25, No. 3, 01.01.2014, p. 353-363.

Research output: Contribution to journalArticle

Papatheodorou, SI, Rohrmann, S, Lopez, D, Bradwin, G, Joshu, CE, Kanarek, N, Nelson, WG, Rifai, N, Platz, EA & Tsilidis, KK 2014, 'Association between endogenous sex steroid hormones and insulin-like growth factor proteins in US men', Cancer Causes and Control, vol. 25, no. 3, pp. 353-363. https://doi.org/10.1007/s10552-013-0336-4
Papatheodorou, Stefania I. ; Rohrmann, Sabine ; Lopez, David ; Bradwin, Gary ; Joshu, Corinne E. ; Kanarek, Norma ; Nelson, William G. ; Rifai, Nader ; Platz, Elizabeth A. ; Tsilidis, Konstantinos K. / Association between endogenous sex steroid hormones and insulin-like growth factor proteins in US men. In: Cancer Causes and Control. 2014 ; Vol. 25, No. 3. pp. 353-363.
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abstract = "Purpose: Sex steroid hormone concentrations and insulin-like growth factor (IGF) proteins have been independently associated with risk of cancer, chronic diseases, and mortality. However, studies that evaluated the inter-relation between the sex hormones and IGF pathways have provided mixed results. We examined the association between endogenous sex hormones and sex hormone-binding globulin (SHBG) with IGF-1 and IGF-binding protein 3 (IGFBP-3) in a population-based sample of US men. Methods: Data from 1,135 men aged 20 years or older participating in the third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Weighted linear regression was used to estimate geometric means and 95 {\%} confidence intervals for IGF-1 and IGFBP-3 concentrations by sex steroid hormones and SHBG after adjusting for age, race/ethnicity, body mass index, waist circumference, alcohol consumption, cigarette smoking, physical activity, diabetes, and mutually adjusting for other sex hormones and SHBG. Results: No significant association was observed between sex steroid hormones, SHBG, and IGF-1 concentrations. Total estradiol ({\%} difference in Q5 - Q1 geometric means -9.7 {\%}; P-trend 0.05) and SHBG ({\%} difference -7.3 {\%}; P-trend 0.02) were modestly inversely associated with IGFBP-3. Total testosterone was modestly inversely associated with IGFBP-3 ({\%} difference -6.2 {\%}; P-trend 0.01), but this association disappeared after adjustment for total estradiol and SHBG ({\%} difference 2.6 {\%}; P-trend 0.23). Androstanediol glucuronide was not associated with IGFBP-3. Conclusions: These findings suggest that there may be inter-relationships between circulating total estradiol, SHBG, and IGFBP-3 concentrations. Future research may consider these inter-relationships when evaluating potential joint effects of the sex hormones and IGF pathways.",
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AU - Lopez, David

AU - Bradwin, Gary

AU - Joshu, Corinne E.

AU - Kanarek, Norma

AU - Nelson, William G.

AU - Rifai, Nader

AU - Platz, Elizabeth A.

AU - Tsilidis, Konstantinos K.

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N2 - Purpose: Sex steroid hormone concentrations and insulin-like growth factor (IGF) proteins have been independently associated with risk of cancer, chronic diseases, and mortality. However, studies that evaluated the inter-relation between the sex hormones and IGF pathways have provided mixed results. We examined the association between endogenous sex hormones and sex hormone-binding globulin (SHBG) with IGF-1 and IGF-binding protein 3 (IGFBP-3) in a population-based sample of US men. Methods: Data from 1,135 men aged 20 years or older participating in the third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Weighted linear regression was used to estimate geometric means and 95 % confidence intervals for IGF-1 and IGFBP-3 concentrations by sex steroid hormones and SHBG after adjusting for age, race/ethnicity, body mass index, waist circumference, alcohol consumption, cigarette smoking, physical activity, diabetes, and mutually adjusting for other sex hormones and SHBG. Results: No significant association was observed between sex steroid hormones, SHBG, and IGF-1 concentrations. Total estradiol (% difference in Q5 - Q1 geometric means -9.7 %; P-trend 0.05) and SHBG (% difference -7.3 %; P-trend 0.02) were modestly inversely associated with IGFBP-3. Total testosterone was modestly inversely associated with IGFBP-3 (% difference -6.2 %; P-trend 0.01), but this association disappeared after adjustment for total estradiol and SHBG (% difference 2.6 %; P-trend 0.23). Androstanediol glucuronide was not associated with IGFBP-3. Conclusions: These findings suggest that there may be inter-relationships between circulating total estradiol, SHBG, and IGFBP-3 concentrations. Future research may consider these inter-relationships when evaluating potential joint effects of the sex hormones and IGF pathways.

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KW - Sex hormone-binding globulin (SHBG)

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