Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women

Katsuhiko Yokoi, Norman G. Egger, V-M Ramanujam, Nancy W. Alcock, Hari H. Dayal, James G. Penland, Harold H. Sandstead

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The objective of this study was to measure relationships between plasma zinc (Zn) concentrations and Zn kinetic parameters and to measure relationships of Zn status with taste acuity, food frequency, and hair Zn in humans. The subjects were 33 premenopausal women not taking oral contraceptives and dietary supplements containing iron and Zn. Main outcomes were plasma Zn concentrations, Zn kinetic parameters based on the three-compartment mammillary model using 67Zn as a tracer, electrical taste detection thresholds, and food frequencies. Lower plasma Zn was significantly (P < 0.01) associated with smaller sizes of the central and the lesser peripheral Zn pools, faster disappearance of tracer from plasma, and higher transfer rate constants from the lesser peripheral pool to the central pool and from the central pool to the greater peripheral pool. The break points in the plasma Zn-Zn kinetics relationship were found between 9.94 and 11.5 μmol/l plasma Zn. Smaller size of the lesser peripheral pool was associated with lower frequency of beef consumption and higher frequency of bran breakfast cereal consumption. Hypozincemic women with plasma Zn <10.7 μmol/l or 700 ng/ml had decreased thresholds of electrical stimulation for gustatory nerves. Our results based on Zn kinetics support the conventional cutoff value of plasma Zn (10.7 μmol/l or 700 ng/ml) between normal and low Zn status.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume285
Issue number5 48-5
StatePublished - Nov 2003

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Kinetic parameters
Zinc
Plasmas
Dietary supplements
Taste Threshold
Food
Beef
Kinetics
Breakfast
Oral Contraceptives
Dietary Supplements
Hair
Electric Stimulation
Rate constants

Keywords

  • Electrical taste threshold
  • Exchangeable zinc pool
  • Inductively coupled plasma-mass spectrometry
  • Iron
  • Zinc-67 stable isotope

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women. / Yokoi, Katsuhiko; Egger, Norman G.; Ramanujam, V-M; Alcock, Nancy W.; Dayal, Hari H.; Penland, James G.; Sandstead, Harold H.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 285, No. 5 48-5, 11.2003.

Research output: Contribution to journalArticle

Yokoi, Katsuhiko ; Egger, Norman G. ; Ramanujam, V-M ; Alcock, Nancy W. ; Dayal, Hari H. ; Penland, James G. ; Sandstead, Harold H. / Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women. In: American Journal of Physiology - Endocrinology and Metabolism. 2003 ; Vol. 285, No. 5 48-5.
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