Association between zinc pool sizes and iron stores in premenopausal women without anaemia

Katsuhiko Yokoi, Harold H. Sandstead, Norman G. Egger, Nancy W. Alcock, V-M Ramanujam, Hari H. Dayal, James G. Penland

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The simultaneous occurrence of Zn and Fe deficiencies in man has been known since the discovery of human Zn deficiency. However, it is not established that low Fe stores per se or Fe-deficiency anaemia infer low Zn status. Therefore our objective was to identify relationships between Zn and Fe status in premenopausal women without anaemia. We also examined the contribution of food frequencies and blood loss to Zn and Fe status. The subjects were thirty-three apparently healthy premenopausal women without anaemia, who were not taking dietary supplements containing Zn or Fe or oral contraceptives. Main outcomes were Zn kinetic parameters based on the three-compartment mammillary model and serum ferritin (SF) concentration; contributing factors were the frequency of consumption of specific foods and menorrhagia. Lower SF was significantly associated with smaller sizes of Zn pools. The breakpoint in the relationship between SF and the lesser peripheral Zn pool was found to be 2.10μg SF/l. SF also correlated positively with frequency of beef consumption and negatively with bleeding through menstrual pads (BTMP). Similar to SF, the Zn pool sizes correlated positively with frequency of beef consumption, and negatively with BTMP. In summary, Zn pool sizes and Fe stores were highly correlated in premenopausal women. SF concentrations <20μg/l suggest an increased likelihood of low Zn status.

Original languageEnglish (US)
Pages (from-to)1214-1223
Number of pages10
JournalBritish Journal of Nutrition
Volume98
Issue number6
DOIs
StatePublished - Dec 2007

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Ferritins
Zinc
Anemia
Iron
Serum
Menstrual Hygiene Products
Hemorrhage
Menorrhagia
Food
Oral Contraceptives
Dietary Supplements

Keywords

  • Exchangeable zinc pool
  • Premenopausal women
  • Serum ferritin

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Yokoi, K., Sandstead, H. H., Egger, N. G., Alcock, N. W., Ramanujam, V-M., Dayal, H. H., & Penland, J. G. (2007). Association between zinc pool sizes and iron stores in premenopausal women without anaemia. British Journal of Nutrition, 98(6), 1214-1223. https://doi.org/10.1017/S0007114507803394

Association between zinc pool sizes and iron stores in premenopausal women without anaemia. / Yokoi, Katsuhiko; Sandstead, Harold H.; Egger, Norman G.; Alcock, Nancy W.; Ramanujam, V-M; Dayal, Hari H.; Penland, James G.

In: British Journal of Nutrition, Vol. 98, No. 6, 12.2007, p. 1214-1223.

Research output: Contribution to journalArticle

Yokoi, Katsuhiko ; Sandstead, Harold H. ; Egger, Norman G. ; Alcock, Nancy W. ; Ramanujam, V-M ; Dayal, Hari H. ; Penland, James G. / Association between zinc pool sizes and iron stores in premenopausal women without anaemia. In: British Journal of Nutrition. 2007 ; Vol. 98, No. 6. pp. 1214-1223.
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