Association of a Sindbis-like virus with Ockelbo disease in Sweden

B. Niklasson, A. Espmark, J. W. LeDuc, T. P. Gargan, W. A. Ennis, R. B. Tesh, A. J. Main

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


An alphavirus isolated from Culiseta mosquitoes has been associated with Ockelbo disease, an exanthema arthralgia syndrome occurring in Sweden. The isolate was made from mosquitoes collected in Edsbyn (central Sweden), an area with considerable Ockelbo disease morbidity. This isolate proved to be indistinguishable from Sindbis virus by complement-fixation and hemagglutination-inhibition tests, and was antigenically related to Sindbis in plaque reduction neutralization tests. Patients with Ockelbo disease developed neutralizing antibodies to the virus in their convalescent sera, suggesting that it is the etiologic agent of the disease.

Original languageEnglish (US)
Pages (from-to)1212-1217
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number6
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Parasitology


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