TY - JOUR
T1 - Association of binge alcohol use with functional outcomes among individuals with COVID-19 infection
AU - Tong, Sebastian T.
AU - Gottlieb, Michael
AU - Ebna Mannan, Imtiaz
AU - Zheng, Zihan
AU - Sinha, Manisha
AU - Santangelo, Michelle
AU - Gatling, Kristyn
AU - Kean, Efrat
AU - Watts, Phillip
AU - Wang, Ralph
AU - Montoy, Juan Carlos
AU - Idris, Ahamed
AU - Macdonald, Samuel
AU - Huebinger, Ryan
AU - Hill, Mandy
AU - O'Laughlin, Kelli N.
AU - Gentile, Nicole L.
AU - Dorney, Jocelyn
AU - Malicki, Caitlin
AU - Elmore, Joann G.
AU - Diaz Roldan, Kate
AU - Chan, Gary
AU - Lin, Zhenqiu
AU - Weinstein, Robert A.
AU - Stephens, Kari A.
N1 - Publisher Copyright:
© 2025 The Author(s).
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Aims: Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals. Methods: Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication and other Substance use screener. Generalized estimating equation models, adjusted for demographic characteristics, social determinants of health, substance use, comorbidities, and COVID-19 vaccine status, were used to assess the association between binge alcohol use and mental and physical functional outcomes. Results: Of 3529 individuals, 23.7% screened positive for binge drinking. At three months, prior self-reported binge drinking was associated with differences in physical function [estimate: 1.08; 95% confidence interval (CI) 0.44, 1.71], pain interference (estimate: -0.86; 95% CI -1.57, -0.15), and physical health (estimate: 1.09; 95% CI 0.43, 1.75). At six months, no associations were found between binge drinking and outcomes. Conclusions: Binge alcohol use before COVID-19 infection was associated with statistically significant but clinically irrelevant improvements in function at three months, which were not sustained at six months. Postinfectious and postpandemic stressors may have played a larger impact on functional outcomes than binge alcohol use. A higher frequency of binge drinking and its association with functional outcomes, particularly among individuals with COVID-19 warrants further study.
AB - Aims: Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals. Methods: Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication and other Substance use screener. Generalized estimating equation models, adjusted for demographic characteristics, social determinants of health, substance use, comorbidities, and COVID-19 vaccine status, were used to assess the association between binge alcohol use and mental and physical functional outcomes. Results: Of 3529 individuals, 23.7% screened positive for binge drinking. At three months, prior self-reported binge drinking was associated with differences in physical function [estimate: 1.08; 95% confidence interval (CI) 0.44, 1.71], pain interference (estimate: -0.86; 95% CI -1.57, -0.15), and physical health (estimate: 1.09; 95% CI 0.43, 1.75). At six months, no associations were found between binge drinking and outcomes. Conclusions: Binge alcohol use before COVID-19 infection was associated with statistically significant but clinically irrelevant improvements in function at three months, which were not sustained at six months. Postinfectious and postpandemic stressors may have played a larger impact on functional outcomes than binge alcohol use. A higher frequency of binge drinking and its association with functional outcomes, particularly among individuals with COVID-19 warrants further study.
KW - alcohol use
KW - binge alcohol
KW - COVID-19 infection
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U2 - 10.1093/alcalc/agae086
DO - 10.1093/alcalc/agae086
M3 - Article
C2 - 39745829
AN - SCOPUS:85215861547
SN - 0735-0414
VL - 60
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
IS - 1
M1 - agae086
ER -