Abstract
We have reported frequent allele loss for the marker D11S12 on chromosome band 11p15.5 in human lung cancer. The smallest common region of allele loss has been refined to approximately 500 kb and is confined between D11S1758 and D11S860. Here, we investigated the association of D11S12 allele loss with epidemiologic, pathologic, and clinical parameters. Analysis of allele loss was performed by Southern blotting on a cohort of 156 patients with lung cancer, and data were interpreted with the use of a phosphorimager. Results were statistically compared with retrospectively collected variables. D11S12 allele loss was found in 88% of small cell carcinomas, 57% of squamous cell carcinomas, and 40% of adenocarcinomas. Allele loss was associated with tumor stage (p = 0.04) and was more frequent in tumors that had already metastasized. These results suggest that a gene in the D11S12 region may be responsible for the metastatic potential of lung cancer. The functional status of this gene may thus be of future value in guiding clinicians on decisions regarding adjuvant and neoadjuvant therapies for patients with lung cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14-19 |
| Number of pages | 6 |
| Journal | Cancer Detection and Prevention |
| Volume | 22 |
| Issue number | 1 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Biomarkers
- Clinical studies
- Epidemiology
- Molecular genetics
- Tumor suppressor genes
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer. / Bepler, G.; Fong, K. M.; Johnson, B. E.; O'Briant, K. C.; Daly, L. A.; Zimmerman, P. V.; Garcia-Blanco, Mariano; Peterson, B.
In: Cancer Detection and Prevention, Vol. 22, No. 1, 1998, p. 14-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer
AU - Bepler, G.
AU - Fong, K. M.
AU - Johnson, B. E.
AU - O'Briant, K. C.
AU - Daly, L. A.
AU - Zimmerman, P. V.
AU - Garcia-Blanco, Mariano
AU - Peterson, B.
PY - 1998
Y1 - 1998
N2 - We have reported frequent allele loss for the marker D11S12 on chromosome band 11p15.5 in human lung cancer. The smallest common region of allele loss has been refined to approximately 500 kb and is confined between D11S1758 and D11S860. Here, we investigated the association of D11S12 allele loss with epidemiologic, pathologic, and clinical parameters. Analysis of allele loss was performed by Southern blotting on a cohort of 156 patients with lung cancer, and data were interpreted with the use of a phosphorimager. Results were statistically compared with retrospectively collected variables. D11S12 allele loss was found in 88% of small cell carcinomas, 57% of squamous cell carcinomas, and 40% of adenocarcinomas. Allele loss was associated with tumor stage (p = 0.04) and was more frequent in tumors that had already metastasized. These results suggest that a gene in the D11S12 region may be responsible for the metastatic potential of lung cancer. The functional status of this gene may thus be of future value in guiding clinicians on decisions regarding adjuvant and neoadjuvant therapies for patients with lung cancer.
AB - We have reported frequent allele loss for the marker D11S12 on chromosome band 11p15.5 in human lung cancer. The smallest common region of allele loss has been refined to approximately 500 kb and is confined between D11S1758 and D11S860. Here, we investigated the association of D11S12 allele loss with epidemiologic, pathologic, and clinical parameters. Analysis of allele loss was performed by Southern blotting on a cohort of 156 patients with lung cancer, and data were interpreted with the use of a phosphorimager. Results were statistically compared with retrospectively collected variables. D11S12 allele loss was found in 88% of small cell carcinomas, 57% of squamous cell carcinomas, and 40% of adenocarcinomas. Allele loss was associated with tumor stage (p = 0.04) and was more frequent in tumors that had already metastasized. These results suggest that a gene in the D11S12 region may be responsible for the metastatic potential of lung cancer. The functional status of this gene may thus be of future value in guiding clinicians on decisions regarding adjuvant and neoadjuvant therapies for patients with lung cancer.
KW - Biomarkers
KW - Clinical studies
KW - Epidemiology
KW - Molecular genetics
KW - Tumor suppressor genes
UR - http://www.scopus.com/inward/record.url?scp=0031930083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031930083&partnerID=8YFLogxK
M3 - Article
VL - 22
SP - 14
EP - 19
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
IS - 1
ER -