Association of chromosome 19 to lung cancer genotypes and phenotypes

Xiangdong Wang, Yong Zhang, Carol L. Nilsson, Frode S. Berven, Per E. Andrén, Elisabet Carlsohn, Peter Horvatovich, Johan Malm, Manuel Fuentes, Ákos Végvári, Charlotte Welinder, Thomas E. Fehniger, Melinda Rezeli, Goutham Edula, Sophia Hober, Toshihide Nishimura, György Marko-Varga

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://www.C-HPP.org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://www.nextprot.org/). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalCancer and Metastasis Reviews
Volume34
Issue number2
DOIs
StatePublished - Jun 1 2015

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Keywords

  • Antibodies
  • Bioinformatics
  • Genes
  • Human disease
  • Mass spectrometry
  • Protein microarray
  • Proteins
  • mRNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wang, X., Zhang, Y., Nilsson, C. L., Berven, F. S., Andrén, P. E., Carlsohn, E., Horvatovich, P., Malm, J., Fuentes, M., Végvári, Á., Welinder, C., Fehniger, T. E., Rezeli, M., Edula, G., Hober, S., Nishimura, T., & Marko-Varga, G. (2015). Association of chromosome 19 to lung cancer genotypes and phenotypes. Cancer and Metastasis Reviews, 34(2), 217-226. https://doi.org/10.1007/s10555-015-9556-2