Association of coagulation factor VII with the risk of myocardial infarction in the Chinese

Qiangjun Cai, Jilin Chen, Huili Ma, Jie Song, Minfu Xu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene Mspl polymorphism and lipid metabolism on FVIIc in the Chinese. Methods: A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FVIIc was measured by one-stage prothrombin time, and FVII genotype was determined after Mspl digestion of polymerase chain reaction-amplified genomic DNA. Serum lipid levels were assessed by routine methods. Results: MI patients had significantly higher levels of FVIIc (119.5% ± 22.7% vs 99.9% ± 21.8%, P < 0.01) and total serum cholesterol (5.80 ± 1.06 mmol/L vs 5.53 ± 1.08 mmol/L, P < 0.05) than controls, but only FVIIc independently correlated with the risk of MI (OR = 1.04, P < 0.01). There were no significant differences in FVII genotype or allele frequency between patients and controls (P > 0.05). Subjects with the Gln353 allele were associated with significantly lower FVIIc levels than Arg353 homozygotes (99.7% ± 19.3% vs 111.4% ± 24.6%, P < 0.05). Serum triglyceride was positively correlated with plasma FVIIc in both control (r = 0.25, P < 0.01) and case (r = 0.87, P < 0.01) groups, but this correlation was restricted to Arg/Arg genotype (r = 0.68, P < 0.01). A significant correlation of total serum cholesterol with FVIIc only appeared in Arg/Arg homozygotes (r = 0.17, P < 0.01). Conclusions: Our findings support the role of plasma FVIIc as a risk factor for MI in Chinese. Plasma triglyceride and FVII gene Mspl polymorphism are two independent determinants of FVIIc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy.

Original languageEnglish (US)
Pages (from-to)1059-1063
Number of pages5
JournalChinese Medical Journal
Volume113
Issue number12
StatePublished - Dec 2000
Externally publishedYes

Fingerprint

Factor VII
Myocardial Infarction
Homozygote
Triglycerides
Serum
Genotype
Lipids
factor VII clotting antigen
Prothrombin Time
Lipid Metabolism
Genes
Digestion
Alleles
Cholesterol
Polymerase Chain Reaction
DNA

Keywords

  • Coagulation factor VII
  • Gene polymorphism
  • Myocardial infarction
  • Triglyceride

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of coagulation factor VII with the risk of myocardial infarction in the Chinese. / Cai, Qiangjun; Chen, Jilin; Ma, Huili; Song, Jie; Xu, Minfu.

In: Chinese Medical Journal, Vol. 113, No. 12, 12.2000, p. 1059-1063.

Research output: Contribution to journalArticle

Cai, Qiangjun ; Chen, Jilin ; Ma, Huili ; Song, Jie ; Xu, Minfu. / Association of coagulation factor VII with the risk of myocardial infarction in the Chinese. In: Chinese Medical Journal. 2000 ; Vol. 113, No. 12. pp. 1059-1063.
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abstract = "Objective: To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene Mspl polymorphism and lipid metabolism on FVIIc in the Chinese. Methods: A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FVIIc was measured by one-stage prothrombin time, and FVII genotype was determined after Mspl digestion of polymerase chain reaction-amplified genomic DNA. Serum lipid levels were assessed by routine methods. Results: MI patients had significantly higher levels of FVIIc (119.5{\%} ± 22.7{\%} vs 99.9{\%} ± 21.8{\%}, P < 0.01) and total serum cholesterol (5.80 ± 1.06 mmol/L vs 5.53 ± 1.08 mmol/L, P < 0.05) than controls, but only FVIIc independently correlated with the risk of MI (OR = 1.04, P < 0.01). There were no significant differences in FVII genotype or allele frequency between patients and controls (P > 0.05). Subjects with the Gln353 allele were associated with significantly lower FVIIc levels than Arg353 homozygotes (99.7{\%} ± 19.3{\%} vs 111.4{\%} ± 24.6{\%}, P < 0.05). Serum triglyceride was positively correlated with plasma FVIIc in both control (r = 0.25, P < 0.01) and case (r = 0.87, P < 0.01) groups, but this correlation was restricted to Arg/Arg genotype (r = 0.68, P < 0.01). A significant correlation of total serum cholesterol with FVIIc only appeared in Arg/Arg homozygotes (r = 0.17, P < 0.01). Conclusions: Our findings support the role of plasma FVIIc as a risk factor for MI in Chinese. Plasma triglyceride and FVII gene Mspl polymorphism are two independent determinants of FVIIc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy.",
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AU - Chen, Jilin

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AU - Song, Jie

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N2 - Objective: To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene Mspl polymorphism and lipid metabolism on FVIIc in the Chinese. Methods: A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FVIIc was measured by one-stage prothrombin time, and FVII genotype was determined after Mspl digestion of polymerase chain reaction-amplified genomic DNA. Serum lipid levels were assessed by routine methods. Results: MI patients had significantly higher levels of FVIIc (119.5% ± 22.7% vs 99.9% ± 21.8%, P < 0.01) and total serum cholesterol (5.80 ± 1.06 mmol/L vs 5.53 ± 1.08 mmol/L, P < 0.05) than controls, but only FVIIc independently correlated with the risk of MI (OR = 1.04, P < 0.01). There were no significant differences in FVII genotype or allele frequency between patients and controls (P > 0.05). Subjects with the Gln353 allele were associated with significantly lower FVIIc levels than Arg353 homozygotes (99.7% ± 19.3% vs 111.4% ± 24.6%, P < 0.05). Serum triglyceride was positively correlated with plasma FVIIc in both control (r = 0.25, P < 0.01) and case (r = 0.87, P < 0.01) groups, but this correlation was restricted to Arg/Arg genotype (r = 0.68, P < 0.01). A significant correlation of total serum cholesterol with FVIIc only appeared in Arg/Arg homozygotes (r = 0.17, P < 0.01). Conclusions: Our findings support the role of plasma FVIIc as a risk factor for MI in Chinese. Plasma triglyceride and FVII gene Mspl polymorphism are two independent determinants of FVIIc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy.

AB - Objective: To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene Mspl polymorphism and lipid metabolism on FVIIc in the Chinese. Methods: A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FVIIc was measured by one-stage prothrombin time, and FVII genotype was determined after Mspl digestion of polymerase chain reaction-amplified genomic DNA. Serum lipid levels were assessed by routine methods. Results: MI patients had significantly higher levels of FVIIc (119.5% ± 22.7% vs 99.9% ± 21.8%, P < 0.01) and total serum cholesterol (5.80 ± 1.06 mmol/L vs 5.53 ± 1.08 mmol/L, P < 0.05) than controls, but only FVIIc independently correlated with the risk of MI (OR = 1.04, P < 0.01). There were no significant differences in FVII genotype or allele frequency between patients and controls (P > 0.05). Subjects with the Gln353 allele were associated with significantly lower FVIIc levels than Arg353 homozygotes (99.7% ± 19.3% vs 111.4% ± 24.6%, P < 0.05). Serum triglyceride was positively correlated with plasma FVIIc in both control (r = 0.25, P < 0.01) and case (r = 0.87, P < 0.01) groups, but this correlation was restricted to Arg/Arg genotype (r = 0.68, P < 0.01). A significant correlation of total serum cholesterol with FVIIc only appeared in Arg/Arg homozygotes (r = 0.17, P < 0.01). Conclusions: Our findings support the role of plasma FVIIc as a risk factor for MI in Chinese. Plasma triglyceride and FVII gene Mspl polymorphism are two independent determinants of FVIIc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy.

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KW - Gene polymorphism

KW - Myocardial infarction

KW - Triglyceride

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