Association of platelet-derived growth factor-D gene polymorphism with ischemic stroke in a Chinese caseg-control study

Sheng Hong Han, Jian Ping Liu, Alai Tan, Ji Peng, Ren Li Zhang, Shi Tong Gao, Da Na Huang, Lei Yu, Chong Jian Wang, Jin Quan Cheng, Shao Fa Nie

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Stroke is a multiple genetic disease. Platelet-derived growth factor-D has been found to be involved in the pathogenesis of atherosclerosis, suggesting possible association between platelet-derived growth factor-D and the development of ischemic stroke. However, little information on the relationship between platelet-derived growth factor-D and stroke is currently available. The aim of this study was to investigate the association between platelet-derived growth factor-D genetic variation and the risk of ischemic stroke in a Chinese population. We conducted a caseg-control study with 309 ischemic stroke patients and 309 sex and age (<5 years)-matched controls. DNA was extracted from the whole blood of each participant. Platelet-derived growth factor-D C/G polymorphism at position +3166 (rs7950273) was detected by TaqMan SNP genotyping assay. Overall, the combined rates of platelet-derived growth factor- D CG and GG are 51% in patients in contrast with 46% in controls. There were no significant differences in the genotype frequencies of platelet-derived growth factor-D +3166 polymorphisms between the patients and controls with history or family history of hypertension or diabetes (P ≤ 0.770). However, among people without history or family history of hypertension or diabetes, platelet-derived growth factor-D CG/GG is significantly more frequently expressed in patients (60%) than in controls (43%) (odds ratio 1.97; 95% confidence interval 1.19g-3.26). This significant association holds after adjustment for age, sex, smoking and alcohol intaking (odds ratio 1.86; 95% confidence interval 1.11g-3.10) (P ≤ 0.018). Our study found that the G allele of rs7950273 of the platelet-derived growth factor-D gene is associated with higher risk of ischemic stroke in a Chinese population without history or family history of hypertension or diabetes. Future studies with larger and ethnically diverse populations are needed to further evaluate the platelet-derived growth factor-D polymorphism and stroke association, as well as its pathophysiological mechanisms.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Volume19
Issue number5
DOIs
StatePublished - Jul 1 2008

Keywords

  • Casecontrol study
  • Ischemic stroke
  • Platelet-derived growth factor-D
  • Polymorphism

ASJC Scopus subject areas

  • Hematology

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    Han, S. H., Liu, J. P., Tan, A., Peng, J., Zhang, R. L., Gao, S. T., Huang, D. N., Yu, L., Wang, C. J., Cheng, J. Q., & Nie, S. F. (2008). Association of platelet-derived growth factor-D gene polymorphism with ischemic stroke in a Chinese caseg-control study. Blood Coagulation and Fibrinolysis, 19(5), 415-419. https://doi.org/10.1097/MBC.0b013e3283049650