Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media

Bin Sheng Sung, Tasnee Chonmaitree, Lyle D. Broemeling, Mary J. Owen, Janak Patel, Dawn C. Hedgpeth, Virgil M. Howie

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Viruses - both alone and in combination with bacteria - have been shown to be a cause of acute otitis media (AOM). Moreover, the presence of virus in middle ear fluid (MEF) interferes with the bacteriologic response to antibiotic treatment in AOM. We studied various factors related to the eradication of bacteria from the MEF of infants and children who had AOM associated with a combination of bacteria and viruses. Of 622 cases of AOM diagnosed and treated between 1985 and 1991, 71 were due to such a combination. Bacteria were eradicated from MEF by 2-4 days of antibiotic treatment in 50 (70%) of these 71 cases; in the remaining 21 cases, the originally identified bacteria persisted or a new pathogenic bacterial species was detected after such treatment. These two groups of cases were compared with respect to the patients' age, sex, race, history of recurrent AOM, duration of respiratory symptoms, and compliance; the type of antibiotic treatment administered; the type of pathogenic bacteria and viruses identified in MEF; the presence of single or multiple pathogens; and the laterality of the disease. The only difference noted was in the type(s) of virus found in MEF. The presence of rhinovirus was associated with a higher rate of bacteriologic failure than was that of respiratory syncytial virus, parainfluenza virus, influenza virus, or other viruses. Our data suggest that the bacteriologic response to antibiotic treatment in bacterial-viral AOM may depend in part on the type(s) of virus present in MEF.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalClinical Infectious Diseases
Volume17
Issue number1
StatePublished - Jul 1993

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Rhinovirus
Otitis Media
Middle Ear
Viruses
Infection
Bacteria
Anti-Bacterial Agents
Therapeutics
Paramyxoviridae Infections
Respiratory Syncytial Viruses
Orthomyxoviridae
Compliance

ASJC Scopus subject areas

  • Immunology

Cite this

Sung, B. S., Chonmaitree, T., Broemeling, L. D., Owen, M. J., Patel, J., Hedgpeth, D. C., & Howie, V. M. (1993). Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media. Clinical Infectious Diseases, 17(1), 38-42.

Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media. / Sung, Bin Sheng; Chonmaitree, Tasnee; Broemeling, Lyle D.; Owen, Mary J.; Patel, Janak; Hedgpeth, Dawn C.; Howie, Virgil M.

In: Clinical Infectious Diseases, Vol. 17, No. 1, 07.1993, p. 38-42.

Research output: Contribution to journalArticle

Sung, BS, Chonmaitree, T, Broemeling, LD, Owen, MJ, Patel, J, Hedgpeth, DC & Howie, VM 1993, 'Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media', Clinical Infectious Diseases, vol. 17, no. 1, pp. 38-42.
Sung BS, Chonmaitree T, Broemeling LD, Owen MJ, Patel J, Hedgpeth DC et al. Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media. Clinical Infectious Diseases. 1993 Jul;17(1):38-42.
Sung, Bin Sheng ; Chonmaitree, Tasnee ; Broemeling, Lyle D. ; Owen, Mary J. ; Patel, Janak ; Hedgpeth, Dawn C. ; Howie, Virgil M. / Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media. In: Clinical Infectious Diseases. 1993 ; Vol. 17, No. 1. pp. 38-42.
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