Association of variants in genes related to the immune response and obesity with BPH in CLUE II

David Lopez, S. B. Peskoe, K. K. Tsilidis, J. Hoffman-Bolton, K. J. Helzlsouer, W. B. Isaacs, M. W. Smith, E. A. Platz

Research output: Contribution to journalArticle

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Abstract

Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (IL1B, IL6, IL8, IL10, TNF, CRP, TLR4 and RNASEL) and genes involved in obesity, including insulin regulation (LEP, ADIPOQ, PPARG and TCF7L2), with BPH.Methods:BPH cases (N=568) and age-frequency matched controls (N=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ≥15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ≤7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.Results:None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for CRP rs1205 (1082C>T), ADIPOQ rs1501299 (276C>A), PPARG rs1801282 (-49C>G) and TCF7L2 rs7903146 (47833T>C). After summing risk alleles, men with ≥4 had an increased BPH risk compared with those with ≤1 (OR, 1.78; 95% CI, 1.10-2.89; P trend =0.006).Conclusions:SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume17
Issue number4
DOIs
StatePublished - Dec 13 2014
Externally publishedYes

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Obesity
Single Nucleotide Polymorphism
Genes
Odds Ratio
Confidence Intervals
Lower Urinary Tract Symptoms
Interleukin-8
Interleukin-10
Interleukin-6
Logistic Models
Alleles
Insulin
Inflammation

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Lopez, D., Peskoe, S. B., Tsilidis, K. K., Hoffman-Bolton, J., Helzlsouer, K. J., Isaacs, W. B., ... Platz, E. A. (2014). Association of variants in genes related to the immune response and obesity with BPH in CLUE II. Prostate Cancer and Prostatic Diseases, 17(4), 353-358. https://doi.org/10.1038/pcan.2014.36

Association of variants in genes related to the immune response and obesity with BPH in CLUE II. / Lopez, David; Peskoe, S. B.; Tsilidis, K. K.; Hoffman-Bolton, J.; Helzlsouer, K. J.; Isaacs, W. B.; Smith, M. W.; Platz, E. A.

In: Prostate Cancer and Prostatic Diseases, Vol. 17, No. 4, 13.12.2014, p. 353-358.

Research output: Contribution to journalArticle

Lopez, D, Peskoe, SB, Tsilidis, KK, Hoffman-Bolton, J, Helzlsouer, KJ, Isaacs, WB, Smith, MW & Platz, EA 2014, 'Association of variants in genes related to the immune response and obesity with BPH in CLUE II', Prostate Cancer and Prostatic Diseases, vol. 17, no. 4, pp. 353-358. https://doi.org/10.1038/pcan.2014.36
Lopez, David ; Peskoe, S. B. ; Tsilidis, K. K. ; Hoffman-Bolton, J. ; Helzlsouer, K. J. ; Isaacs, W. B. ; Smith, M. W. ; Platz, E. A. / Association of variants in genes related to the immune response and obesity with BPH in CLUE II. In: Prostate Cancer and Prostatic Diseases. 2014 ; Vol. 17, No. 4. pp. 353-358.
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abstract = "Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (IL1B, IL6, IL8, IL10, TNF, CRP, TLR4 and RNASEL) and genes involved in obesity, including insulin regulation (LEP, ADIPOQ, PPARG and TCF7L2), with BPH.Methods:BPH cases (N=568) and age-frequency matched controls (N=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ≥15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ≤7. Age-adjusted odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated using logistic regression.Results:None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for CRP rs1205 (1082C>T), ADIPOQ rs1501299 (276C>A), PPARG rs1801282 (-49C>G) and TCF7L2 rs7903146 (47833T>C). After summing risk alleles, men with ≥4 had an increased BPH risk compared with those with ≤1 (OR, 1.78; 95{\%} CI, 1.10-2.89; P trend =0.006).Conclusions:SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.",
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AU - Lopez, David

AU - Peskoe, S. B.

AU - Tsilidis, K. K.

AU - Hoffman-Bolton, J.

AU - Helzlsouer, K. J.

AU - Isaacs, W. B.

AU - Smith, M. W.

AU - Platz, E. A.

PY - 2014/12/13

Y1 - 2014/12/13

N2 - Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (IL1B, IL6, IL8, IL10, TNF, CRP, TLR4 and RNASEL) and genes involved in obesity, including insulin regulation (LEP, ADIPOQ, PPARG and TCF7L2), with BPH.Methods:BPH cases (N=568) and age-frequency matched controls (N=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ≥15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ≤7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.Results:None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for CRP rs1205 (1082C>T), ADIPOQ rs1501299 (276C>A), PPARG rs1801282 (-49C>G) and TCF7L2 rs7903146 (47833T>C). After summing risk alleles, men with ≥4 had an increased BPH risk compared with those with ≤1 (OR, 1.78; 95% CI, 1.10-2.89; P trend =0.006).Conclusions:SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.

AB - Background: Chronic inflammation and obesity may contribute to the genesis or progression of BPH and BPH-associated lower urinary tract symptoms (LUTS). The influence of variants in genes related to these states on BPH has not been studied extensively. Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response genes (IL1B, IL6, IL8, IL10, TNF, CRP, TLR4 and RNASEL) and genes involved in obesity, including insulin regulation (LEP, ADIPOQ, PPARG and TCF7L2), with BPH.Methods:BPH cases (N=568) and age-frequency matched controls (N=568) were selected from among adult male CLUE II cohort participants who responded in 2000 to a mailed questionnaire. BPH was defined as BPH surgery, use of BPH medications or symptomatic BPH (American Urological Association Symptom Index Score ≥15). Controls were men who had not had BPH surgery, did not use BPH medications and whose symptom score was ≤7. Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.Results:None of the candidate SNPs was statistically significantly associated with BPH. However, we could not rule out possible weak associations for CRP rs1205 (1082C>T), ADIPOQ rs1501299 (276C>A), PPARG rs1801282 (-49C>G) and TCF7L2 rs7903146 (47833T>C). After summing risk alleles, men with ≥4 had an increased BPH risk compared with those with ≤1 (OR, 1.78; 95% CI, 1.10-2.89; P trend =0.006).Conclusions:SNPs in genes related to immune response and obesity, especially in combination, may be associated with BPH.

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