Association of visual field severity and parapapillary retinal blood flow in open-angle glaucoma

Sunil Deokule, Gianmarco Vizzeri, Andreas Boehm, Christopher Bowd, Robert N. Weinreb

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

PURPOSE: To examine the association of the parapapillary blood flow parameters with severity of visual field loss (VFL) in open-angle glaucoma (OAG) patients. DESIGN: Observational clinical study. METHODS: Fifty-two patients with OAG and 30 normal subjects were studied prospectively. Parapapillary blood flow parameters were obtained for superotemporal and inferotemporal quadrants using the scanning laser Doppler flowmeter. Mean deviation score was used to determine the severity of VFL both as continuous variable and stratified by severity: no VFL (OAG A) ≤ 2dB, mild VFL (OAG B) from 2.1 to 6dB and moderate-severe VFL (OAG C) >6 dB. In the OAG patients with an abnormal Glaucoma Hemifield Test, the hemifield with a predominant VFL was determined. Linear regression analysis and analysis of covariance were used to assess the relationship between the severity of the VFL and the parapapillary blood flow parameters. The variance in mean parapapillary blood flow was assessed using standard deviation (SD) and coefficient of variation (COV). RESULTS: There was no correlation between the severity of VFL and parapapillary blood flow parameters. Variance in the mean parapapillary blood flow was significantly greater in OAG patients with VFL compared with OAG patients without VFL and normal subjects for the superotemporal quadrant (SD, P=0.04; COV, P=0.02) and the inferotemporal quadrant (SD, P<0.02; COV, P=0.02). Results for COV were confirmed for the inferotemporal quadrant in analysis of covariance after adjusting for age and intraocular pressure (F=1.60, P=0.04). CONCLUSION: The parapapillary blood flow did not correlate with VFL. However, the variance in meanparapapillary blood flow was significantly larger in OAG patients with VFL, thus suggesting vascular abnormality.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalJournal of Glaucoma
Volume19
Issue number5
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Open Angle Glaucoma
Visual Fields
Flowmeters
Intraocular Pressure
Glaucoma
Observational Studies
Blood Vessels
Linear Models
Lasers
Regression Analysis

Keywords

  • Parapapillary blood flow
  • Primary open angle glaucoma
  • Scanning laser Doppler flowmetry
  • Standard automated perimetry

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Association of visual field severity and parapapillary retinal blood flow in open-angle glaucoma. / Deokule, Sunil; Vizzeri, Gianmarco; Boehm, Andreas; Bowd, Christopher; Weinreb, Robert N.

In: Journal of Glaucoma, Vol. 19, No. 5, 06.2010, p. 293-298.

Research output: Contribution to journalArticle

Deokule, Sunil ; Vizzeri, Gianmarco ; Boehm, Andreas ; Bowd, Christopher ; Weinreb, Robert N. / Association of visual field severity and parapapillary retinal blood flow in open-angle glaucoma. In: Journal of Glaucoma. 2010 ; Vol. 19, No. 5. pp. 293-298.
@article{73929169d8704cca98b75ab0a38deddf,
title = "Association of visual field severity and parapapillary retinal blood flow in open-angle glaucoma",
abstract = "PURPOSE: To examine the association of the parapapillary blood flow parameters with severity of visual field loss (VFL) in open-angle glaucoma (OAG) patients. DESIGN: Observational clinical study. METHODS: Fifty-two patients with OAG and 30 normal subjects were studied prospectively. Parapapillary blood flow parameters were obtained for superotemporal and inferotemporal quadrants using the scanning laser Doppler flowmeter. Mean deviation score was used to determine the severity of VFL both as continuous variable and stratified by severity: no VFL (OAG A) ≤ 2dB, mild VFL (OAG B) from 2.1 to 6dB and moderate-severe VFL (OAG C) >6 dB. In the OAG patients with an abnormal Glaucoma Hemifield Test, the hemifield with a predominant VFL was determined. Linear regression analysis and analysis of covariance were used to assess the relationship between the severity of the VFL and the parapapillary blood flow parameters. The variance in mean parapapillary blood flow was assessed using standard deviation (SD) and coefficient of variation (COV). RESULTS: There was no correlation between the severity of VFL and parapapillary blood flow parameters. Variance in the mean parapapillary blood flow was significantly greater in OAG patients with VFL compared with OAG patients without VFL and normal subjects for the superotemporal quadrant (SD, P=0.04; COV, P=0.02) and the inferotemporal quadrant (SD, P<0.02; COV, P=0.02). Results for COV were confirmed for the inferotemporal quadrant in analysis of covariance after adjusting for age and intraocular pressure (F=1.60, P=0.04). CONCLUSION: The parapapillary blood flow did not correlate with VFL. However, the variance in meanparapapillary blood flow was significantly larger in OAG patients with VFL, thus suggesting vascular abnormality.",
keywords = "Parapapillary blood flow, Primary open angle glaucoma, Scanning laser Doppler flowmetry, Standard automated perimetry",
author = "Sunil Deokule and Gianmarco Vizzeri and Andreas Boehm and Christopher Bowd and Weinreb, {Robert N.}",
year = "2010",
month = "6",
doi = "10.1097/IJG.0b013e3181b6e5b9",
language = "English (US)",
volume = "19",
pages = "293--298",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Association of visual field severity and parapapillary retinal blood flow in open-angle glaucoma

AU - Deokule, Sunil

AU - Vizzeri, Gianmarco

AU - Boehm, Andreas

AU - Bowd, Christopher

AU - Weinreb, Robert N.

PY - 2010/6

Y1 - 2010/6

N2 - PURPOSE: To examine the association of the parapapillary blood flow parameters with severity of visual field loss (VFL) in open-angle glaucoma (OAG) patients. DESIGN: Observational clinical study. METHODS: Fifty-two patients with OAG and 30 normal subjects were studied prospectively. Parapapillary blood flow parameters were obtained for superotemporal and inferotemporal quadrants using the scanning laser Doppler flowmeter. Mean deviation score was used to determine the severity of VFL both as continuous variable and stratified by severity: no VFL (OAG A) ≤ 2dB, mild VFL (OAG B) from 2.1 to 6dB and moderate-severe VFL (OAG C) >6 dB. In the OAG patients with an abnormal Glaucoma Hemifield Test, the hemifield with a predominant VFL was determined. Linear regression analysis and analysis of covariance were used to assess the relationship between the severity of the VFL and the parapapillary blood flow parameters. The variance in mean parapapillary blood flow was assessed using standard deviation (SD) and coefficient of variation (COV). RESULTS: There was no correlation between the severity of VFL and parapapillary blood flow parameters. Variance in the mean parapapillary blood flow was significantly greater in OAG patients with VFL compared with OAG patients without VFL and normal subjects for the superotemporal quadrant (SD, P=0.04; COV, P=0.02) and the inferotemporal quadrant (SD, P<0.02; COV, P=0.02). Results for COV were confirmed for the inferotemporal quadrant in analysis of covariance after adjusting for age and intraocular pressure (F=1.60, P=0.04). CONCLUSION: The parapapillary blood flow did not correlate with VFL. However, the variance in meanparapapillary blood flow was significantly larger in OAG patients with VFL, thus suggesting vascular abnormality.

AB - PURPOSE: To examine the association of the parapapillary blood flow parameters with severity of visual field loss (VFL) in open-angle glaucoma (OAG) patients. DESIGN: Observational clinical study. METHODS: Fifty-two patients with OAG and 30 normal subjects were studied prospectively. Parapapillary blood flow parameters were obtained for superotemporal and inferotemporal quadrants using the scanning laser Doppler flowmeter. Mean deviation score was used to determine the severity of VFL both as continuous variable and stratified by severity: no VFL (OAG A) ≤ 2dB, mild VFL (OAG B) from 2.1 to 6dB and moderate-severe VFL (OAG C) >6 dB. In the OAG patients with an abnormal Glaucoma Hemifield Test, the hemifield with a predominant VFL was determined. Linear regression analysis and analysis of covariance were used to assess the relationship between the severity of the VFL and the parapapillary blood flow parameters. The variance in mean parapapillary blood flow was assessed using standard deviation (SD) and coefficient of variation (COV). RESULTS: There was no correlation between the severity of VFL and parapapillary blood flow parameters. Variance in the mean parapapillary blood flow was significantly greater in OAG patients with VFL compared with OAG patients without VFL and normal subjects for the superotemporal quadrant (SD, P=0.04; COV, P=0.02) and the inferotemporal quadrant (SD, P<0.02; COV, P=0.02). Results for COV were confirmed for the inferotemporal quadrant in analysis of covariance after adjusting for age and intraocular pressure (F=1.60, P=0.04). CONCLUSION: The parapapillary blood flow did not correlate with VFL. However, the variance in meanparapapillary blood flow was significantly larger in OAG patients with VFL, thus suggesting vascular abnormality.

KW - Parapapillary blood flow

KW - Primary open angle glaucoma

KW - Scanning laser Doppler flowmetry

KW - Standard automated perimetry

UR - http://www.scopus.com/inward/record.url?scp=77954022300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954022300&partnerID=8YFLogxK

U2 - 10.1097/IJG.0b013e3181b6e5b9

DO - 10.1097/IJG.0b013e3181b6e5b9

M3 - Article

VL - 19

SP - 293

EP - 298

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 5

ER -