Association of zoonotic Ljungan virus with intrauterine fetal deaths

Bo Niklasson, Annika Samsioe, Nikos Papadogiannakis, Anne Kawecki, Birger Hörnfeldt, George Saade, William Klitz

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

BACKGROUND: It has recently been shown that Ljungan virus (LV) is associated with disease in its wild rodent reservoir. In addition, it has been demonstrated that LV causes malformations and perinatal death in a mouse model. The question was therefore raised whether LV is a zoonotic agent in humans. METHODS: Population fluctuations of native rodents in Sweden were compared to the incidence of intrauterine fetal deaths (IUFDs) using the Swedish national hospitalization database. Formalin-fixed tissues from cases of IUFD were investigated using LV-specific immunohistochemistry. RESULTS: Variation in the incidence of IUFDs closely tracked the fluctuations in native rodent populations. LV was detected in the brain tissue in 4 of 10 cases of IUFDs investigated by immunochemistry. LV was also detected in the placenta in 5 of the 10 IUFD cases, but in none of 20 placentas from normal pregnancies. CONCLUSIONS: LV may play an important role in IUFDs.

Original languageEnglish (US)
Pages (from-to)488-493
Number of pages6
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume79
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Parechovirus
Fetal Death
Zoonoses
Rodentia
Placenta
Immunochemistry
Incidence
Sweden
Formaldehyde
Population
Cause of Death
Hospitalization
Immunohistochemistry
Databases
Pregnancy

Keywords

  • Epidemiology
  • Immunohistochemistry
  • Infection
  • Intrauterine deaths
  • Ljungan virus
  • Zoonotic

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Association of zoonotic Ljungan virus with intrauterine fetal deaths. / Niklasson, Bo; Samsioe, Annika; Papadogiannakis, Nikos; Kawecki, Anne; Hörnfeldt, Birger; Saade, George; Klitz, William.

In: Birth Defects Research Part A - Clinical and Molecular Teratology, Vol. 79, No. 6, 06.2007, p. 488-493.

Research output: Contribution to journalArticle

Niklasson, B, Samsioe, A, Papadogiannakis, N, Kawecki, A, Hörnfeldt, B, Saade, G & Klitz, W 2007, 'Association of zoonotic Ljungan virus with intrauterine fetal deaths', Birth Defects Research Part A - Clinical and Molecular Teratology, vol. 79, no. 6, pp. 488-493. https://doi.org/10.1002/bdra.20359
Niklasson, Bo ; Samsioe, Annika ; Papadogiannakis, Nikos ; Kawecki, Anne ; Hörnfeldt, Birger ; Saade, George ; Klitz, William. / Association of zoonotic Ljungan virus with intrauterine fetal deaths. In: Birth Defects Research Part A - Clinical and Molecular Teratology. 2007 ; Vol. 79, No. 6. pp. 488-493.
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