Association study of the CTH 1364 G>T polymorphism with coronary artery disease in the Greek population

Efstathia Giannakopoulou, Fotios Konstantinou, Georgia Ragia, Zisis Gerontitis, Anna Tavridou, Andreas Papapetropoulos, Dimitrios Mikroulis, Vangelis G. Manolopoulos

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cystathionine γ-lyase enzyme, which is encoded by the CTH gene, is responsible for hydrogen sulfide (H 2 S) production in the endothelium. The CTH 1364 G>T polymorphism may alter the CTH expression and H 2 S bioavailability, thus leading to atherosclerosis and coronary artery disease (CAD). We examined the potential association of the CTH 1364 G>T polymorphism with CAD. The CTH 1364 G>T polymorphism was determined in 178 coronary artery bypass grafting (CABG) patients and 156 non-atherosclerotic controls of Greek Caucasian origin using the PCR-RFLP method. No significant difference in the frequency of the CTH 1364 G>T genotypes (p = 0.281) and alleles (p = 0.265) was found between the CABG patients and controls. After conducting stratification according to sex, analysis showed a numerical difference in the CTH 1364 TT genotype frequency in female participants that did not reach statistical significance (16.3% and 8.5% in the CABG and controls, respectively, p = 0.26). The frequency of the CTH 1364 TT genotype between the male CABG patients and controls did not differ (p = 0.507). The CTH 1364 G>T polymorphism was not associated with CAD in the studied population. However, interestingly, a higher - if not significantly so - CTH 1364 TT genotype frequency was present in female CABG patients compared with female controls. Larger studies are necessary to conclude on the potential overall or gender-driven association between CTH 1364 G>T gene polymorphism and CAD.

Original languageEnglish (US)
Article number20180033
JournalDrug Metabolism and Personalized Therapy
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • coronary artery disease
  • CTH genetic variation
  • cystathionine γ-lyase
  • hydrogen sulfide
  • polymorphism

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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    Giannakopoulou, E., Konstantinou, F., Ragia, G., Gerontitis, Z., Tavridou, A., Papapetropoulos, A., Mikroulis, D., & Manolopoulos, V. G. (2019). Association study of the CTH 1364 G>T polymorphism with coronary artery disease in the Greek population. Drug Metabolism and Personalized Therapy, 34(1), [20180033]. https://doi.org/10.1515/dmpt-2018-0033