Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture

Philipp Hendrix, Paul M. Foreman, Robert M. Starke, Mark R. Harrigan, Winfield S. Fisher, Nilesh A. Vyas, Robert H. Lipsky, Minkuan Lin, Beverly C. Walters, R. Shane Tubbs, Mohammadali Mohajel Shoja, Jean Francois Pittet, Mali Mathru, Christoph J. Griessenauer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Purpose Aneurysm size is an important risk factor for aneurysm rupture. The pathophysiologic mechanisms underlying aneurysm growth remain poorly understood. Endothelin signaling is critical for cerebrovascular blood flow regulation. The influence of endothelin single nucleotide polymorphisms (SNPs) on aneurysm size at the time of rupture has not been previously investigated. Methods Eight common endothelin SNPs were assessed using blood samples from aneurysmal subarachnoid hemorrhage (aSAH) patients enrolled in the Cerebral Aneurysm Renin Angiotensin System study, a prospective, 2-center study that enrolled aSAH patients and controls in the United States from 2012–2015. Genetic evaluation was performed using 5′exonnuclease (Taqman) genotyping assays. Associations of endothelin SNPs and aneurysm size were analyzed. Results One-hundred and forty-nine blood samples from aSAH patients were available for analysis. There was a dominant effect of the G allele of the endothelin receptor type A (EDNRA) SNP rs5335 on aneurysm size ≥7 mm (odds ratio = 2.740, 95% confidence interval 1.039–7.228, P = 0.042) along with associations with race and presence of additional aneurysms. The other endothelin SNPs were not associated with aneurysm size. Conclusions The EDNRA SNP rs5335 was independently associated with aneurysms ≥7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA SNP rs5335 may develop larger aneurysms before rupture.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalWorld Neurosurgery
Volume102
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Endothelins
Aneurysm
Rupture
Single Nucleotide Polymorphism
Endothelin A Receptors
Subarachnoid Hemorrhage
Intracranial Aneurysm
Alleles
Renin-Angiotensin System
Odds Ratio
Prospective Studies
Confidence Intervals

Keywords

  • Aneurysm size
  • Endothelin
  • Polymorphism
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Hendrix, P., Foreman, P. M., Starke, R. M., Harrigan, M. R., Fisher, W. S., Vyas, N. A., ... Griessenauer, C. J. (2017). Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture. World Neurosurgery, 102, 253-257. https://doi.org/10.1016/j.wneu.2017.03.041

Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture. / Hendrix, Philipp; Foreman, Paul M.; Starke, Robert M.; Harrigan, Mark R.; Fisher, Winfield S.; Vyas, Nilesh A.; Lipsky, Robert H.; Lin, Minkuan; Walters, Beverly C.; Tubbs, R. Shane; Mohajel Shoja, Mohammadali; Pittet, Jean Francois; Mathru, Mali; Griessenauer, Christoph J.

In: World Neurosurgery, Vol. 102, 01.06.2017, p. 253-257.

Research output: Contribution to journalArticle

Hendrix, P, Foreman, PM, Starke, RM, Harrigan, MR, Fisher, WS, Vyas, NA, Lipsky, RH, Lin, M, Walters, BC, Tubbs, RS, Mohajel Shoja, M, Pittet, JF, Mathru, M & Griessenauer, CJ 2017, 'Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture', World Neurosurgery, vol. 102, pp. 253-257. https://doi.org/10.1016/j.wneu.2017.03.041
Hendrix P, Foreman PM, Starke RM, Harrigan MR, Fisher WS, Vyas NA et al. Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture. World Neurosurgery. 2017 Jun 1;102:253-257. https://doi.org/10.1016/j.wneu.2017.03.041
Hendrix, Philipp ; Foreman, Paul M. ; Starke, Robert M. ; Harrigan, Mark R. ; Fisher, Winfield S. ; Vyas, Nilesh A. ; Lipsky, Robert H. ; Lin, Minkuan ; Walters, Beverly C. ; Tubbs, R. Shane ; Mohajel Shoja, Mohammadali ; Pittet, Jean Francois ; Mathru, Mali ; Griessenauer, Christoph J. / Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture. In: World Neurosurgery. 2017 ; Vol. 102. pp. 253-257.
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abstract = "Background and Purpose Aneurysm size is an important risk factor for aneurysm rupture. The pathophysiologic mechanisms underlying aneurysm growth remain poorly understood. Endothelin signaling is critical for cerebrovascular blood flow regulation. The influence of endothelin single nucleotide polymorphisms (SNPs) on aneurysm size at the time of rupture has not been previously investigated. Methods Eight common endothelin SNPs were assessed using blood samples from aneurysmal subarachnoid hemorrhage (aSAH) patients enrolled in the Cerebral Aneurysm Renin Angiotensin System study, a prospective, 2-center study that enrolled aSAH patients and controls in the United States from 2012–2015. Genetic evaluation was performed using 5′exonnuclease (Taqman) genotyping assays. Associations of endothelin SNPs and aneurysm size were analyzed. Results One-hundred and forty-nine blood samples from aSAH patients were available for analysis. There was a dominant effect of the G allele of the endothelin receptor type A (EDNRA) SNP rs5335 on aneurysm size ≥7 mm (odds ratio = 2.740, 95{\%} confidence interval 1.039–7.228, P = 0.042) along with associations with race and presence of additional aneurysms. The other endothelin SNPs were not associated with aneurysm size. Conclusions The EDNRA SNP rs5335 was independently associated with aneurysms ≥7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA SNP rs5335 may develop larger aneurysms before rupture.",
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AU - Hendrix, Philipp

AU - Foreman, Paul M.

AU - Starke, Robert M.

AU - Harrigan, Mark R.

AU - Fisher, Winfield S.

AU - Vyas, Nilesh A.

AU - Lipsky, Robert H.

AU - Lin, Minkuan

AU - Walters, Beverly C.

AU - Tubbs, R. Shane

AU - Mohajel Shoja, Mohammadali

AU - Pittet, Jean Francois

AU - Mathru, Mali

AU - Griessenauer, Christoph J.

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N2 - Background and Purpose Aneurysm size is an important risk factor for aneurysm rupture. The pathophysiologic mechanisms underlying aneurysm growth remain poorly understood. Endothelin signaling is critical for cerebrovascular blood flow regulation. The influence of endothelin single nucleotide polymorphisms (SNPs) on aneurysm size at the time of rupture has not been previously investigated. Methods Eight common endothelin SNPs were assessed using blood samples from aneurysmal subarachnoid hemorrhage (aSAH) patients enrolled in the Cerebral Aneurysm Renin Angiotensin System study, a prospective, 2-center study that enrolled aSAH patients and controls in the United States from 2012–2015. Genetic evaluation was performed using 5′exonnuclease (Taqman) genotyping assays. Associations of endothelin SNPs and aneurysm size were analyzed. Results One-hundred and forty-nine blood samples from aSAH patients were available for analysis. There was a dominant effect of the G allele of the endothelin receptor type A (EDNRA) SNP rs5335 on aneurysm size ≥7 mm (odds ratio = 2.740, 95% confidence interval 1.039–7.228, P = 0.042) along with associations with race and presence of additional aneurysms. The other endothelin SNPs were not associated with aneurysm size. Conclusions The EDNRA SNP rs5335 was independently associated with aneurysms ≥7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA SNP rs5335 may develop larger aneurysms before rupture.

AB - Background and Purpose Aneurysm size is an important risk factor for aneurysm rupture. The pathophysiologic mechanisms underlying aneurysm growth remain poorly understood. Endothelin signaling is critical for cerebrovascular blood flow regulation. The influence of endothelin single nucleotide polymorphisms (SNPs) on aneurysm size at the time of rupture has not been previously investigated. Methods Eight common endothelin SNPs were assessed using blood samples from aneurysmal subarachnoid hemorrhage (aSAH) patients enrolled in the Cerebral Aneurysm Renin Angiotensin System study, a prospective, 2-center study that enrolled aSAH patients and controls in the United States from 2012–2015. Genetic evaluation was performed using 5′exonnuclease (Taqman) genotyping assays. Associations of endothelin SNPs and aneurysm size were analyzed. Results One-hundred and forty-nine blood samples from aSAH patients were available for analysis. There was a dominant effect of the G allele of the endothelin receptor type A (EDNRA) SNP rs5335 on aneurysm size ≥7 mm (odds ratio = 2.740, 95% confidence interval 1.039–7.228, P = 0.042) along with associations with race and presence of additional aneurysms. The other endothelin SNPs were not associated with aneurysm size. Conclusions The EDNRA SNP rs5335 was independently associated with aneurysms ≥7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA SNP rs5335 may develop larger aneurysms before rupture.

KW - Aneurysm size

KW - Endothelin

KW - Polymorphism

KW - Subarachnoid hemorrhage

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