Abstract
Maternal stress is a risk factor for adverse pregnancy outcomes (APOs). This study evaluates the associations of prenatal stress and APOs with maternal stress years after pregnancy. The 10-item Perceived Stress Scale (PSS) (0–40 range) was completed in the first and third trimesters, and 2–7 years after delivery among a subsample (n = 4161) of nulliparous women enrolled at eight US medical centers between 2010 and 2013 in a prospective, observational cohort study. Demographics, medical history, and presence of APOs (gestational diabetes (GDM), hypertensive disorders of pregnancy (HDP), preeclampsia (PE), and medically indicated or spontaneous preterm birth (miPTB, sPTB)) were obtained. The associations of prenatal PSS and the presence of APOs with PSS scores years after delivery were estimated using multivariable linear regression. Mean PSS scores were 12.5 (95% CI 12.3, 12.7) and 11.3 (95% CI 11.1, 11.5) in the first and third trimesters respectively and 14.9 (95% CI 14.7, 15.1) 2–7 years later, an average increase of 2.4 points (95% CI 2.2, 2.6) from the start of pregnancy. Regressing PSS scores after delivery on first-trimester PSS and PSS increase through pregnancy showed positive associations, with coefficients (95% CI) of 2.8 (2.7, 3.0) and 1.5 (1.3, 1.7) per 5-point change, respectively. Adding APO indicator variables separately showed higher PSS scores for women with HDP (0.7 [0.1, 1.3]), PE (1.3 [0.6, 2.1]), and miPTB (1.3 [0.2, 2.4]), but not those with GDM or sPTB. In this geographically and demographically diverse sample, prenatal stress and some APOs were positively associated with stress levels 2–7 years after pregnancy. ClinicalTrials.gov Registration number NCT02231398.
| Original language | English (US) |
|---|---|
| Journal | Archives of Women's Mental Health |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Adverse pregnancy outcomes
- Perceived stress
- Preeclampsia (5)
- Prenatal maternal stress
- Preterm birth
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Psychiatry and Mental health
Cite this
Associations of perceived prenatal stress and adverse pregnancy outcomes with perceived stress years after delivery. / for the NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks.
In: Archives of Women's Mental Health, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations of perceived prenatal stress and adverse pregnancy outcomes with perceived stress years after delivery
AU - for the NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks
AU - Monk, Catherine
AU - Webster, Rachel S.
AU - McNeil, Rebecca B.
AU - Parker, Corette B.
AU - Catov, Janet M.
AU - Greenland, Philip
AU - Bairey Merz, C. Noel
AU - Silver, Robert M.
AU - Simhan, Hyagriv N.
AU - Ehrenthal, Deborah B.
AU - Chung, Judith H.
AU - Haas, David M.
AU - Mercer, Brian M.
AU - Parry, Samuel
AU - Polito, Lu Ann
AU - Reddy, Uma M.
AU - Saade, George
AU - Grobman, William A.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Maternal stress is a risk factor for adverse pregnancy outcomes (APOs). This study evaluates the associations of prenatal stress and APOs with maternal stress years after pregnancy. The 10-item Perceived Stress Scale (PSS) (0–40 range) was completed in the first and third trimesters, and 2–7 years after delivery among a subsample (n = 4161) of nulliparous women enrolled at eight US medical centers between 2010 and 2013 in a prospective, observational cohort study. Demographics, medical history, and presence of APOs (gestational diabetes (GDM), hypertensive disorders of pregnancy (HDP), preeclampsia (PE), and medically indicated or spontaneous preterm birth (miPTB, sPTB)) were obtained. The associations of prenatal PSS and the presence of APOs with PSS scores years after delivery were estimated using multivariable linear regression. Mean PSS scores were 12.5 (95% CI 12.3, 12.7) and 11.3 (95% CI 11.1, 11.5) in the first and third trimesters respectively and 14.9 (95% CI 14.7, 15.1) 2–7 years later, an average increase of 2.4 points (95% CI 2.2, 2.6) from the start of pregnancy. Regressing PSS scores after delivery on first-trimester PSS and PSS increase through pregnancy showed positive associations, with coefficients (95% CI) of 2.8 (2.7, 3.0) and 1.5 (1.3, 1.7) per 5-point change, respectively. Adding APO indicator variables separately showed higher PSS scores for women with HDP (0.7 [0.1, 1.3]), PE (1.3 [0.6, 2.1]), and miPTB (1.3 [0.2, 2.4]), but not those with GDM or sPTB. In this geographically and demographically diverse sample, prenatal stress and some APOs were positively associated with stress levels 2–7 years after pregnancy. ClinicalTrials.gov Registration number NCT02231398.
AB - Maternal stress is a risk factor for adverse pregnancy outcomes (APOs). This study evaluates the associations of prenatal stress and APOs with maternal stress years after pregnancy. The 10-item Perceived Stress Scale (PSS) (0–40 range) was completed in the first and third trimesters, and 2–7 years after delivery among a subsample (n = 4161) of nulliparous women enrolled at eight US medical centers between 2010 and 2013 in a prospective, observational cohort study. Demographics, medical history, and presence of APOs (gestational diabetes (GDM), hypertensive disorders of pregnancy (HDP), preeclampsia (PE), and medically indicated or spontaneous preterm birth (miPTB, sPTB)) were obtained. The associations of prenatal PSS and the presence of APOs with PSS scores years after delivery were estimated using multivariable linear regression. Mean PSS scores were 12.5 (95% CI 12.3, 12.7) and 11.3 (95% CI 11.1, 11.5) in the first and third trimesters respectively and 14.9 (95% CI 14.7, 15.1) 2–7 years later, an average increase of 2.4 points (95% CI 2.2, 2.6) from the start of pregnancy. Regressing PSS scores after delivery on first-trimester PSS and PSS increase through pregnancy showed positive associations, with coefficients (95% CI) of 2.8 (2.7, 3.0) and 1.5 (1.3, 1.7) per 5-point change, respectively. Adding APO indicator variables separately showed higher PSS scores for women with HDP (0.7 [0.1, 1.3]), PE (1.3 [0.6, 2.1]), and miPTB (1.3 [0.2, 2.4]), but not those with GDM or sPTB. In this geographically and demographically diverse sample, prenatal stress and some APOs were positively associated with stress levels 2–7 years after pregnancy. ClinicalTrials.gov Registration number NCT02231398.
KW - Adverse pregnancy outcomes
KW - Perceived stress
KW - Preeclampsia (5)
KW - Prenatal maternal stress
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=85068325750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068325750&partnerID=8YFLogxK
U2 - 10.1007/s00737-019-00970-8
DO - 10.1007/s00737-019-00970-8
M3 - Article
AN - SCOPUS:85068325750
JO - Archives of Women's Mental Health
JF - Archives of Women's Mental Health
SN - 1434-1816
ER -