Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

Keyphrases

• Neurotoxicity 100%
• Overexpression 100%
• Astrocytes 100%
• Rotenone 100%
• Rat Model of Parkinson's Disease 100%
• DJ-1 100%
• Overexpressing 33%
• Parkinson's Disease 33%
• Alpha-synuclein (α-syn) 33%
• Dopaminergic Neurons 33%
• Substantia Nigra 33%
• Neurodegeneration 16%
• Striatum 16%
• Oxidative Damage 16%
• Oxidative Stress 16%
• Pathological Features 16%
• Phosphorylation 16%
• Mitochondrial Dysfunction 16%
• Tropism 16%
• Pseudotype 16%
• Transgene Expression 16%
• Idiopathic Parkinson's Disease 16%
• Mitochondrial Physiology 16%
• Neuroinflammation 16%
• Immunoreactivity 16%
• Microglial Activation 16%
• Non-cell Autonomous 16%
• Lewis Rats 16%
• LAMP2 16%
• Chaperone Activity 16%
• Glial Response 16%
• Astroglial Cells 16%
• Primary Neurons 16%
• Astroglial 16%
• Astrocytic 16%
• Gene Transfer Vector 16%
• Redox Protein 16%
• Neuronal Oxidative Stress 16%
• Putative Functions 16%
• Stress Activation 16%
• Vector Delivery 16%
• Neuroprotective Function 16%
• Chaperone-mediated Autophagy 16%
• DJ-1 Protein 16%
• Glial Cell Type 16%
• Proteolytic Regulation 16%
• Lentiviral Gene Transfer 16%

Neuroscience

• Neurotoxicity 100%
• Astrocyte 100%
• Parkinson's Disease 100%
• Rotenone 100%
• In Vivo 33%
• Oxidative Stress 33%
• Transgene 33%
• Synuclein 33%
• Substantia nigra 33%
• Dopaminergic Neuron 33%
• Neurodegeneration 16%
• In Vitro 16%
• Striatum 16%
• Glial Cells 16%
• Neuroprotective Agent 16%
• Proteasome 16%
• Shuttle Vector 16%
• Chaperone-Mediated Autophagy 16%
• Protein Deglycase DJ-1 16%