Astrocytes are HIV reservoirs in the brain: A cell type with poor HIV infectivity and replication but efficient cell-to-cell viral transfer

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Infectivity 100%
• Cell-to-cell 100%
• Astrocytes 100%
• Viral Transfer 100%
• Viral Reservoir 40%
• Antiretroviral Therapy 30%
• Small Populations 20%
• Human Immunodeficiency virus-1 Infection 20%
• Primary Astrocytes 20%
• Infected Individual 10%
• Viral Replication 10%
• Macrophages 10%
• Latency 10%
• In Vitro Experiment 10%
• Tumor Necrosis Factor-α 10%
• Latently Infected 10%
• Central Nervous System 10%
• Methamphetamine 10%
• Virion 10%
• Improved Detection 10%
• Neighboring Cells 10%
• Culture Results 10%
• Histone Deacetylase Inhibitor (HDACi) 10%
• Long-term Culture 10%
• New Humanities 10%
• Human Brain Tissue 10%
• Viral Production 10%
• Brain Microglia 10%
• Primary Astrocyte Culture 10%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• Astrocyte 100%
• Replication 100%
• Infection 100%
• Viral Reservoir 33%
• In Vitro 16%
• Macrophage 8%
• Viral Replication 8%
• Virion 8%
• Central Nervous System 8%
• Microglia 8%
• Tissue Section 8%
• Brain Tissue 8%
• TNF Inhibitor 8%
• Astrocyte Culture 8%
• Histone 8%