ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

Yogesh C. Awasthi, S. V. Singh, H. Ahmad, L. W. Wronski, S. K. Srivastava, E. F. LaBelle

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione - xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume91
Issue number1-2
DOIs
StatePublished - Mar 1989

Keywords

  • ATPase
  • erythrocytes
  • glutathione
  • membranes
  • transport
  • xenobiotics

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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