ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

Yogesh C. Awasthi, S. V. Singh, H. Ahmad, L. W. Wronski, Satish Srivastava, E. F. LaBelle

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione - xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume91
Issue number1-2
DOIs
StatePublished - Mar 1989

Fingerprint

Active Biological Transport
Erythrocyte Membrane
Xenobiotics
Glutathione
Adenosine Triphosphatases
Adenosine Triphosphate
Erythrocytes
Membranes
Glutathione Disulfide
Plasmas
S-(2,4-dinitrophenyl)glutathione
S-(dinitrophenyl)glutathione ATPase

Keywords

  • ATPase
  • erythrocytes
  • glutathione
  • membranes
  • transport
  • xenobiotics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Awasthi, Y. C., Singh, S. V., Ahmad, H., Wronski, L. W., Srivastava, S., & LaBelle, E. F. (1989). ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane. Molecular and Cellular Biochemistry, 91(1-2), 131-136. https://doi.org/10.1007/BF00228088

ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane. / Awasthi, Yogesh C.; Singh, S. V.; Ahmad, H.; Wronski, L. W.; Srivastava, Satish; LaBelle, E. F.

In: Molecular and Cellular Biochemistry, Vol. 91, No. 1-2, 03.1989, p. 131-136.

Research output: Contribution to journalArticle

Awasthi, YC, Singh, SV, Ahmad, H, Wronski, LW, Srivastava, S & LaBelle, EF 1989, 'ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane', Molecular and Cellular Biochemistry, vol. 91, no. 1-2, pp. 131-136. https://doi.org/10.1007/BF00228088
Awasthi, Yogesh C. ; Singh, S. V. ; Ahmad, H. ; Wronski, L. W. ; Srivastava, Satish ; LaBelle, E. F. / ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane. In: Molecular and Cellular Biochemistry. 1989 ; Vol. 91, No. 1-2. pp. 131-136.
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