ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

Yogesh C. Awasthi; S. V. Singh; H. Ahmad; L. W. Wronski; S. K. Srivastava; E. F. LaBelle

doi:10.1007/BF00228088

ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

Yogesh C. Awasthi
, S. V. Singh
, H. Ahmad
, L. W. Wronski
, S. K. Srivastava
, E. F. LaBelle

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione - xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.

Original language	English (US)
Pages (from-to)	131-136
Number of pages	6
Journal	Molecular and Cellular Biochemistry
Volume	91
Issue number	1-2
DOIs	https://doi.org/10.1007/BF00228088
State	Published - Mar 1989
Externally published	Yes

Keywords

ATPase
erythrocytes
glutathione
membranes
transport
xenobiotics

ASJC Scopus subject areas

Molecular Biology
Clinical Biochemistry
Cell Biology

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10.1007/BF00228088

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title = "ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane",

abstract = "We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione - xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.",

keywords = "ATPase, erythrocytes, glutathione, membranes, transport, xenobiotics",

author = "Awasthi, \{Yogesh C.\} and Singh, \{S. V.\} and H. Ahmad and Wronski, \{L. W.\} and Srivastava, \{S. K.\} and LaBelle, \{E. F.\}",

year = "1989",

month = mar,

doi = "10.1007/BF00228088",

language = "English (US)",

volume = "91",

pages = "131--136",

journal = "Molecular and Cellular Biochemistry",

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T1 - ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

AU - Awasthi, Yogesh C.

AU - Singh, S. V.

AU - Ahmad, H.

AU - Wronski, L. W.

AU - Srivastava, S. K.

AU - LaBelle, E. F.

PY - 1989/3

Y1 - 1989/3

N2 - We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione - xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.

AB - We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione - xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.

KW - ATPase

KW - erythrocytes

KW - glutathione

KW - membranes

KW - transport

KW - xenobiotics

UR - https://www.scopus.com/pages/publications/0024358068

UR - https://www.scopus.com/pages/publications/0024358068#tab=citedBy

U2 - 10.1007/BF00228088

DO - 10.1007/BF00228088

M3 - Article

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AN - SCOPUS:0024358068

SN - 0300-8177

VL - 91

SP - 131

EP - 136

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

IS - 1-2

ER -

ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

Abstract

Keywords

ASJC Scopus subject areas

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