ATP suppresses activity in slowly adapting but not rapidly adapting mechanoreceptors in toad skin

James B. Fallon, Rosario Maroto, Owen Hamill, Uwe Proske

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To test the possible role of ATP in transducing or modulating touch sensation, an isolated skin-nerve preparation from the toad, Bufo marinus, perfused on the inner side, was used to examine the effects of ATP on slowly adapting (SA) and rapidly adapting (RA) mechanoreceptors, identified by ramp and hold indentation of the skin. ATP (1-50 mM) did not generate impulse activity in either SA or RA mechanoreceptors nor increase their responses to mechanical stimulation. Instead, ATP (≥5mM) reversibly and selectively suppressed impulse discharge from SA mechanoreceptors. Our results indicate that while ATP may modulate the responses of specific touch receptors, it is not involved in transducing touch into nerve impulses.

Original languageEnglish (US)
Pages (from-to)1443-1446
Number of pages4
JournalNeuroReport
Volume13
Issue number11
StatePublished - Aug 7 2002

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Mechanoreceptors
Anura
Adenosine Triphosphate
Touch
Skin
Bufo marinus
Architectural Accessibility
Action Potentials

Keywords

  • Amphibian skin
  • ATP suppression
  • Mechanotransduction
  • Merkel cell
  • Muscle spindle
  • P2Y modulation
  • Pain
  • Slowly adapting
  • Touch receptors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

ATP suppresses activity in slowly adapting but not rapidly adapting mechanoreceptors in toad skin. / Fallon, James B.; Maroto, Rosario; Hamill, Owen; Proske, Uwe.

In: NeuroReport, Vol. 13, No. 11, 07.08.2002, p. 1443-1446.

Research output: Contribution to journalArticle

Fallon, James B. ; Maroto, Rosario ; Hamill, Owen ; Proske, Uwe. / ATP suppresses activity in slowly adapting but not rapidly adapting mechanoreceptors in toad skin. In: NeuroReport. 2002 ; Vol. 13, No. 11. pp. 1443-1446.
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