ATP synthase subunit c storage in the polymorphonucleocytes of late infantile and juvenile batten patients

Naseem H. Ansari, Jay D. Cook, Peeyush Khanna, Satish K. Srivastava

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In late infantile and juvenile forms of neuronal ceroid lipofuscinosis, commonly known as Batten disease (BD), ATP synthase subunit c accumulates in the lysosomes of neural cells. By using polyclonal antibodies, raised against bovine liver subunit c and an image analysis system for the quantification of antibody-linked alkaline phosphatase reaction, we have demonstrated that polymorphonucleocytes (PMN) from a late infantile and a juvenile BD patient stored several-fold more subunit c as compared to normal PMN.

Original languageEnglish (US)
Pages (from-to)455-462
Number of pages8
JournalInternational Journal of Developmental Neuroscience
Volume13
Issue number5
DOIs
StatePublished - Aug 1995

Keywords

  • ATP synthase subunit c
  • Batten disease
  • polymorphonucleocytes

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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