TY - JOUR
T1 - Attempted Suppression of the Interferon Response in the Mouse (34900)
AU - Borden, Ernest C.
AU - Murphy, Frederick A.
AU - Gary, George W.
PY - 1970/7
Y1 - 1970/7
N2 - The interferon response after pretreatment of the adult mouse with heparin, dimethylbenzanthracene, actinomycin, antilymphocyte serum antimacrophage serum, phytohemagglutinin, or after splenectomy, was investigated. After the mice were pretreated, interferon response was induced by intravenous injection of Newcastle disease virus; serum interferon was then quantitated. None of the treatments completely suppressed interferon production. These findings support the hypothesis that interferon is synthesized in vivo at several sites and by many cell types.
AB - The interferon response after pretreatment of the adult mouse with heparin, dimethylbenzanthracene, actinomycin, antilymphocyte serum antimacrophage serum, phytohemagglutinin, or after splenectomy, was investigated. After the mice were pretreated, interferon response was induced by intravenous injection of Newcastle disease virus; serum interferon was then quantitated. None of the treatments completely suppressed interferon production. These findings support the hypothesis that interferon is synthesized in vivo at several sites and by many cell types.
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U2 - 10.3181/00379727-134-34900
DO - 10.3181/00379727-134-34900
M3 - Article
C2 - 5431378
AN - SCOPUS:0014819359
SN - 0037-9727
VL - 134
SP - 865
EP - 869
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -