Attempted Suppression of the Interferon Response in the Mouse (34900)

Ernest C. Borden, Frederick A. Murphy, George W. Gary

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The interferon response after pretreatment of the adult mouse with heparin, dimethylbenzanthracene, actinomycin, antilymphocyte serum antimacrophage serum, phytohemagglutinin, or after splenectomy, was investigated. After the mice were pretreated, interferon response was induced by intravenous injection of Newcastle disease virus; serum interferon was then quantitated. None of the treatments completely suppressed interferon production. These findings support the hypothesis that interferon is synthesized in vivo at several sites and by many cell types.

Original languageEnglish (US)
Pages (from-to)865-869
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume134
Issue number3
DOIs
StatePublished - Jul 1970

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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