Attenuated and lethal variants of pichindé virus induce differential patterns of NF-κB activation suggesting a potential target for novel therapeutics

Gavin C. Bowick; Susan M. Fennewald; Lihong Zhang; Xianbin Yang; Judith F. Aronson; Robert E. Shope; Bruce A. Luxon; David G. Gorenstein; Norbert K. Herzog

doi:10.1089/vim.2009.0034

Attenuated and lethal variants of pichindé virus induce differential patterns of NF-κB activation suggesting a potential target for novel therapeutics

Gavin C. Bowick, Susan M. Fennewald, Lihong Zhang, Xianbin Yang, Judith F. Aronson, Robert E. Shope, Bruce A. Luxon, David G. Gorenstein, Norbert K. Herzog

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.

Original language	English (US)
Pages (from-to)	457-462
Number of pages	6
Journal	Viral Immunology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1089/vim.2009.0034
State	Published - Dec 1 2009

ASJC Scopus subject areas

Immunology
Molecular Medicine
Virology

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10.1089/vim.2009.0034

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title = "Attenuated and lethal variants of pichind{\'e} virus induce differential patterns of NF-κB activation suggesting a potential target for novel therapeutics",

abstract = "Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.",

author = "Bowick, {Gavin C.} and Fennewald, {Susan M.} and Lihong Zhang and Xianbin Yang and Aronson, {Judith F.} and Shope, {Robert E.} and Luxon, {Bruce A.} and Gorenstein, {David G.} and Herzog, {Norbert K.}",

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AU - Bowick, Gavin C.

AU - Fennewald, Susan M.

AU - Zhang, Lihong

AU - Yang, Xianbin

AU - Aronson, Judith F.

AU - Shope, Robert E.

AU - Luxon, Bruce A.

AU - Gorenstein, David G.

AU - Herzog, Norbert K.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.

AB - Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.

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Attenuated and lethal variants of pichindé virus induce differential patterns of NF-κB activation suggesting a potential target for novel therapeutics

Abstract

ASJC Scopus subject areas

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