Attenuated and lethal variants of pichindé virus induce differential patterns of NF-κB activation suggesting a potential target for novel therapeutics

Gavin C. Bowick, Susan M. Fennewald, Lihong Zhang, Xianbin Yang, Judith F. Aronson, Robert E. Shope, Bruce A. Luxon, David G. Gorenstein, Norbert K. Herzog

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.

Original languageEnglish (US)
Pages (from-to)457-462
Number of pages6
JournalViral Immunology
Volume22
Issue number6
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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