Attenuated transcriptional responses to oxidative stress in the aged rat brain

Li Qi Tong, Tracy Toliver-Kinsky, Michael Edwards, David K. Rassin, Karin Werrbach-Perez, J. Regino Perez-Polo

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The aged nervous system displays impaired cognitive functions, and these impairments are exacerbated in several neurodegenerative diseases. A role for oxidative stress has been suggested for several of these age-3associated dysfunctions. In addition, recovery from more acute traumatic insults that also generate oxidative stress is impaired in the aged. Here we examine the response of aged rat hippocampi to normobaric hyperoxia treatments and demonstrate an attenuation in the DNA binding activity of the AP-1 and nuclear factor-κB transcription factors, which are important components of stress response signal transduction pathways and can determine shifts in cellular commitments to necrosis, apoptosis, or functional recovery in the central nervous system.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalJournal of Neuroscience Research
Volume70
Issue number3
DOIs
StatePublished - Nov 2 2002

Keywords

  • AP-1
  • APE/Ref-1
  • Aging
  • Hyperoxia
  • NF-κB
  • Reperfusion

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Tong, L. Q., Toliver-Kinsky, T., Edwards, M., Rassin, D. K., Werrbach-Perez, K., & Regino Perez-Polo, J. (2002). Attenuated transcriptional responses to oxidative stress in the aged rat brain. Journal of Neuroscience Research, 70(3), 318-326. https://doi.org/10.1002/jnr.10428