Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men

Johannes D. Veldhuis, Randall Urban, German Lizarralde, Michael L. Johnson, Ali Iranmanesh

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Abstract

To evaluate the impact of healthy aging on specific features of endogenous LH secretion and clearance, we applied deconvolution analysis to 24-h serum immunoradiometric LH concentration series obtained in normal men whose ages ranged from 21-73 yr. Deconvolution analysis was employed to quantitate the number, amplitude, duration, and mass of individual LH secretory bursts underlying the serum LH concentration profiles, and simultaneously estimate the half-life of LH in individual men. Plasma total and free testosterone and estradiol concentrations and body mass index (a measure of relative adiposity) were studied as possible significant covariates of age and LH secretion. We found that age was a negative determinant of LH secretory burst amplitude (r = -0.519, P = 0.013), and a positive predictor of LH secretory burst frequency (r = +0.435, P = 0.043) and basal LH secretory rates (r = +0.486, P = 0.029). Increasing age also correlated positively with LH secretory burst half-duration (duration of the secretory event at half-maximal amplitude, r = +0.656, P < 0.001). In contrast, age did not relate to daily pulsatile LH production rate, the mass of LH secreted per burst, or the mean (24-h) serum concentration of immunoradiometric LH. Age correlated negatively with serum free testosterone (r = -0.622, P = 0.0034) but not estradiol concentrations. The serum free testosterone concentration also declined significantly with increasing body mass index (r = -0.519, P = 0.023). Although there were strong combined effects of age, body mass index, and LH secretory burst amplitude on serum free testosterone concentrations (P = 0.0006, multi-r value 0.820), LH secretory burst amplitude was the most prominent single determinant of blood androgen concentrations.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume75
Issue number3
StatePublished - Sep 1992

Fingerprint

Luteinizing Hormone
Testosterone
Aging of materials
Deconvolution
Serum
Estradiol
Body Mass Index
Secretory Rate
Androgens
Blood
Adiposity
Plasmas
Half-Life

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men. / Veldhuis, Johannes D.; Urban, Randall; Lizarralde, German; Johnson, Michael L.; Iranmanesh, Ali.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 75, No. 3, 09.1992, p. 707-713.

Research output: Contribution to journalArticle

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