Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

A. A. Fadl, J. Sha, G. R. Klimpel, J. P. Olano, C. L. Galindo, A. K. Chopra

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

Original languageEnglish (US)
Pages (from-to)8433-8436
Number of pages4
JournalInfection and immunity
Volume73
Issue number12
DOIs
StatePublished - Dec 1 2005

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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