Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

A. A. Fadl, Jian Sha, G. R. Klimpel, Juan Olano, C. L. Galindo, Ashok Chopra

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

Original languageEnglish (US)
Pages (from-to)8433-8436
Number of pages4
JournalInfection and Immunity
Volume73
Issue number12
DOIs
StatePublished - Dec 2005

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Salmonella enterica
Peptidoglycan
Lipoproteins
Lipopolysaccharides
Salmonella
Mutagenesis
Genes
Serogroup
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide. / Fadl, A. A.; Sha, Jian; Klimpel, G. R.; Olano, Juan; Galindo, C. L.; Chopra, Ashok.

In: Infection and Immunity, Vol. 73, No. 12, 12.2005, p. 8433-8436.

Research output: Contribution to journalArticle

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