Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

A. A. Fadl; J. Sha; G. R. Klimpel; J. P. Olano; C. L. Galindo; A. K. Chopra

doi:10.1128/IAI.73.12.8433-8436.2005

Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

A. A. Fadl, J. Sha, G. R. Klimpel, J. P. Olano, C. L. Galindo, A. K. Chopra

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11 Scopus citations

Abstract

We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

Original language	English (US)
Pages (from-to)	8433-8436
Number of pages	4
Journal	Infection and immunity
Volume	73
Issue number	12
DOIs	https://doi.org/10.1128/IAI.73.12.8433-8436.2005
State	Published - Dec 2005

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.12.8433-8436.2005

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abstract = "We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.",

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AU - Fadl, A. A.

AU - Sha, J.

AU - Klimpel, G. R.

AU - Olano, J. P.

AU - Galindo, C. L.

AU - Chopra, A. K.

PY - 2005/12

Y1 - 2005/12

N2 - We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

AB - We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

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DO - 10.1128/IAI.73.12.8433-8436.2005

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JO - Infection and immunity

JF - Infection and immunity

IS - 12

ER -

Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

Abstract

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