Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

A. A. Fadl; J. Sha; G. R. Klimpel; J. P. Olano; C. L. Galindo; A. K. Chopra

doi:10.1128/IAI.73.12.8433-8436.2005

Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

A. A. Fadl
, J. Sha
, G. R. Klimpel
, J. P. Olano
, C. L. Galindo
, A. K. Chopra

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

Original language	English (US)
Pages (from-to)	8433-8436
Number of pages	4
Journal	Infection and immunity
Volume	73
Issue number	12
DOIs	https://doi.org/10.1128/IAI.73.12.8433-8436.2005
State	Published - Dec 2005

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.12.8433-8436.2005

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abstract = "We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.",

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AU - Fadl, A. A.

AU - Sha, J.

AU - Klimpel, G. R.

AU - Olano, J. P.

AU - Galindo, C. L.

AU - Chopra, A. K.

PY - 2005/12

Y1 - 2005/12

N2 - We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

AB - We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

UR - https://www.scopus.com/pages/publications/28444478045

UR - https://www.scopus.com/pages/publications/28444478045#tab=citedBy

U2 - 10.1128/IAI.73.12.8433-8436.2005

DO - 10.1128/IAI.73.12.8433-8436.2005

M3 - Article

C2 - 16299345

AN - SCOPUS:28444478045

SN - 0019-9567

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JO - Infection and immunity

JF - Infection and immunity

IS - 12

ER -

Attenuation of Salmonella enterica serovar typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide

Abstract

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