Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey

M. Onofrj, M. F. Ghilardi, M. Basciani, J. Martinez-Tica, A. Glover

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Volume20
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Somatosensory Evoked Potentials
Median Nerve
Haplorhini
Macaca fascicularis
Neurotoxins
Parkinsonian Disorders
Primates
Dopamine

Keywords

  • cynomolgus monkey
  • MPTP
  • Parkinson's disease
  • Somatosensory Evoked Potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey. / Onofrj, M.; Ghilardi, M. F.; Basciani, M.; Martinez-Tica, J.; Glover, A.

In: Neurophysiologie Clinique / Clinical Neurophysiology, Vol. 20, No. 4, 1990, p. 283-293.

Research output: Contribution to journalArticle

Onofrj, M. ; Ghilardi, M. F. ; Basciani, M. ; Martinez-Tica, J. ; Glover, A. / Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey. In: Neurophysiologie Clinique / Clinical Neurophysiology. 1990 ; Vol. 20, No. 4. pp. 283-293.
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