Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey

M. Onofrj; M. F. Ghilardi; M. Basciani; J. Martinez-Tica; A. Glover

doi:10.1016/S0987-7053(05)80118-2

Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey

M. Onofrj, M. F. Ghilardi, M. Basciani, J. Martinez-Tica, A. Glover

Anesthesiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.

Original language	English (US)
Pages (from-to)	283-293
Number of pages	11
Journal	Neurophysiologie Clinique / Clinical Neurophysiology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/S0987-7053(05)80118-2
State	Published - Oct 1990

Keywords

cynomolgus monkey
MPTP
Parkinson's disease
Somatosensory Evoked Potentials

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1016/S0987-7053(05)80118-2

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title = "Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey",

abstract = "Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.",

keywords = "cynomolgus monkey, MPTP, Parkinson's disease, Somatosensory Evoked Potentials",

author = "M. Onofrj and Ghilardi, {M. F.} and M. Basciani and J. Martinez-Tica and A. Glover",

year = "1990",

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T1 - Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey

AU - Onofrj, M.

AU - Ghilardi, M. F.

AU - Basciani, M.

AU - Martinez-Tica, J.

AU - Glover, A.

PY - 1990/10

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N2 - Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.

AB - Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.

KW - cynomolgus monkey

KW - MPTP

KW - Parkinson's disease

KW - Somatosensory Evoked Potentials

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Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey

Abstract

Keywords

ASJC Scopus subject areas

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