Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey

M. Onofrj, M. F. Ghilardi, M. Basciani, J. Martinez-Tica, A. Glover

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14 Scopus citations


Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.

Original languageEnglish (US)
Pages (from-to)283-293
Number of pages11
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Issue number4
StatePublished - Oct 1990



  • cynomolgus monkey
  • MPTP
  • Parkinson's disease
  • Somatosensory Evoked Potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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