Abstract
Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.
| Original language | English |
|---|---|
| Pages (from-to) | 283-293 |
| Number of pages | 11 |
| Journal | Neurophysiologie Clinique / Clinical Neurophysiology |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- cynomolgus monkey
- MPTP
- Parkinson's disease
- Somatosensory Evoked Potentials
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey. / Onofrj, M.; Ghilardi, M. F.; Basciani, M.; Martinez-Tica, J.; Glover, A.
In: Neurophysiologie Clinique / Clinical Neurophysiology, Vol. 20, No. 4, 1990, p. 283-293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey
AU - Onofrj, M.
AU - Ghilardi, M. F.
AU - Basciani, M.
AU - Martinez-Tica, J.
AU - Glover, A.
PY - 1990
Y1 - 1990
N2 - Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.
AB - Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients.
KW - cynomolgus monkey
KW - MPTP
KW - Parkinson's disease
KW - Somatosensory Evoked Potentials
UR - http://www.scopus.com/inward/record.url?scp=0025037524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025037524&partnerID=8YFLogxK
U2 - 10.1016/S0987-7053(05)80118-2
DO - 10.1016/S0987-7053(05)80118-2
M3 - Article
C2 - 2290412
AN - SCOPUS:0025037524
VL - 20
SP - 283
EP - 293
JO - Neurophysiologie Clinique
JF - Neurophysiologie Clinique
SN - 0987-7053
IS - 4
ER -