@article{87091d9a91f24be9847f8c6b4a3517eb,
title = "Attitudes of clinicians following large-scale pharmacogenomics implementation",
abstract = "Clinician attitudes toward multiplexed genomic testing may be vital to the success of translational programs. We surveyed clinicians at an academic medical center about their views on a large pharmacogenomics implementation, the PREDICT (Pharmacogenomic Resource for Enhanced Decisions in Care and Treatment) program. Participants were asked about test ordering, major factors influencing use of results, expectations of efficacy and responsibility for applying results to patient care. Virtually all respondents (99%) agreed that pharmacogenomics variants influence patients' response to drug therapy. The majority (92%) favored immediate, active notification when a clinically significant drug-genome interaction was present. However, clinicians were divided on which providers were responsible for acting on a result when a prescription change was indicated and whether patients should be directly notified of a significant result. We concluded genotype results were valued for tailoring prescriptions, but clinicians do not agree on how to appropriately assign clinical responsibility for actionable results from a multiplexed panel.",
author = "Peterson, {J. F.} and Field, {J. R.} and Y. Shi and Schildcrout, {J. S.} and Denny, {J. C.} and McGregor, {T. L.} and {Van Driest}, {S. L.} and Pulley, {J. M.} and Lubin, {I. M.} and M. Laposata and Roden, {D. M.} and Clayton, {E. W.}",
note = "Funding Information: We thank Lisa Price for assisting with the survey. This project was funded by Vanderbilt University, the Centers for Disease Control and Prevention (U47CI000824), the National Heart, Lung, and Blood Institute (U01HL122904, U01HL105198), the National Institute for General Medical Sciences (U19HL065962), the National Human Genome Research Institute (U01HG006378), the National Center for Advancing Translational Sciences (UL1TR000445), KL2TR000446 and NICHD K23 HD000001. The analyses described herein are solely the responsibility of the authors alone and do not necessarily represent official views of the Centers for Disease Control and Prevention or the National Institutes of Health. In addition, the funding sources had no role in the study design, the collection, analysis and interpretation of data, manuscript preparation or the decision to submit the paper for publication. Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited.",
year = "2016",
month = aug,
day = "1",
doi = "10.1038/tpj.2015.57",
language = "English (US)",
volume = "16",
pages = "393--398",
journal = "Pharmacogenomics Journal",
issn = "1470-269X",
publisher = "Nature Publishing Group",
number = "4",
}