Auer rod-like inclusions in prolymphocytic leukemia

H. S. Juneja, S. Rajaraman, J. B. Alperin, D. F. Bainton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Auer rod-like inclusions (ARLI) can be seen in B cell malignancies but are very rare in prolymphocytic leukemia (PLL). Prolymphocytes with ARLI from a patient with PLL were examined using cytochemical and immunochemical techniques and transmission electronmicroscopy (EM). The lymphoblastic cells gave a positive reaction with antibodies to the gamma heavy chains and kappa light chain. On EM the ARLI were 1-2 μm long, consisting of electron-dense crystalline matrix, with a periodicity of 60 Å and contained within a single unit membrane. The production of IgG by PLL cells with ARLI has not been previously reported. It is emphasized that in PLL the lymphoblasts can have inclusions resembling Auer rods. Cytochemical and immunochemical studies should be done to avoid a misdiagnosis of acute nonlymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalActa Haematologica
Volume77
Issue number2
StatePublished - 1987

Fingerprint

Prolymphocytic Leukemia
Periodicity
Diagnostic Errors
Acute Myeloid Leukemia
B-Lymphocytes
Immunoglobulin G
Electrons
Light
Membranes
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

Juneja, H. S., Rajaraman, S., Alperin, J. B., & Bainton, D. F. (1987). Auer rod-like inclusions in prolymphocytic leukemia. Acta Haematologica, 77(2), 115-119.

Auer rod-like inclusions in prolymphocytic leukemia. / Juneja, H. S.; Rajaraman, S.; Alperin, J. B.; Bainton, D. F.

In: Acta Haematologica, Vol. 77, No. 2, 1987, p. 115-119.

Research output: Contribution to journalArticle

Juneja, HS, Rajaraman, S, Alperin, JB & Bainton, DF 1987, 'Auer rod-like inclusions in prolymphocytic leukemia', Acta Haematologica, vol. 77, no. 2, pp. 115-119.
Juneja HS, Rajaraman S, Alperin JB, Bainton DF. Auer rod-like inclusions in prolymphocytic leukemia. Acta Haematologica. 1987;77(2):115-119.
Juneja, H. S. ; Rajaraman, S. ; Alperin, J. B. ; Bainton, D. F. / Auer rod-like inclusions in prolymphocytic leukemia. In: Acta Haematologica. 1987 ; Vol. 77, No. 2. pp. 115-119.
@article{89c89d27c59f45398d02c469576551a1,
title = "Auer rod-like inclusions in prolymphocytic leukemia",
abstract = "Auer rod-like inclusions (ARLI) can be seen in B cell malignancies but are very rare in prolymphocytic leukemia (PLL). Prolymphocytes with ARLI from a patient with PLL were examined using cytochemical and immunochemical techniques and transmission electronmicroscopy (EM). The lymphoblastic cells gave a positive reaction with antibodies to the gamma heavy chains and kappa light chain. On EM the ARLI were 1-2 μm long, consisting of electron-dense crystalline matrix, with a periodicity of 60 {\AA} and contained within a single unit membrane. The production of IgG by PLL cells with ARLI has not been previously reported. It is emphasized that in PLL the lymphoblasts can have inclusions resembling Auer rods. Cytochemical and immunochemical studies should be done to avoid a misdiagnosis of acute nonlymphoblastic leukemia.",
author = "Juneja, {H. S.} and S. Rajaraman and Alperin, {J. B.} and Bainton, {D. F.}",
year = "1987",
language = "English (US)",
volume = "77",
pages = "115--119",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Auer rod-like inclusions in prolymphocytic leukemia

AU - Juneja, H. S.

AU - Rajaraman, S.

AU - Alperin, J. B.

AU - Bainton, D. F.

PY - 1987

Y1 - 1987

N2 - Auer rod-like inclusions (ARLI) can be seen in B cell malignancies but are very rare in prolymphocytic leukemia (PLL). Prolymphocytes with ARLI from a patient with PLL were examined using cytochemical and immunochemical techniques and transmission electronmicroscopy (EM). The lymphoblastic cells gave a positive reaction with antibodies to the gamma heavy chains and kappa light chain. On EM the ARLI were 1-2 μm long, consisting of electron-dense crystalline matrix, with a periodicity of 60 Å and contained within a single unit membrane. The production of IgG by PLL cells with ARLI has not been previously reported. It is emphasized that in PLL the lymphoblasts can have inclusions resembling Auer rods. Cytochemical and immunochemical studies should be done to avoid a misdiagnosis of acute nonlymphoblastic leukemia.

AB - Auer rod-like inclusions (ARLI) can be seen in B cell malignancies but are very rare in prolymphocytic leukemia (PLL). Prolymphocytes with ARLI from a patient with PLL were examined using cytochemical and immunochemical techniques and transmission electronmicroscopy (EM). The lymphoblastic cells gave a positive reaction with antibodies to the gamma heavy chains and kappa light chain. On EM the ARLI were 1-2 μm long, consisting of electron-dense crystalline matrix, with a periodicity of 60 Å and contained within a single unit membrane. The production of IgG by PLL cells with ARLI has not been previously reported. It is emphasized that in PLL the lymphoblasts can have inclusions resembling Auer rods. Cytochemical and immunochemical studies should be done to avoid a misdiagnosis of acute nonlymphoblastic leukemia.

UR - http://www.scopus.com/inward/record.url?scp=0023196892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023196892&partnerID=8YFLogxK

M3 - Article

VL - 77

SP - 115

EP - 119

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 2

ER -