Augmentation of host resistance to Candida albicans infection in ascites tumor-bearing mice

Y. Okawa, Y. Murata, Makiko Kobayashi, M. Suzuki, S. Suzuki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalMicrobiology and Immunology
Volume36
Issue number5
StatePublished - 1992
Externally publishedYes

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Candida albicans
Ascites
Infection
Neoplasms
Bone Marrow Cells
Neutrophils
Cell Count
Sarcoma 180
Kidney
Granulocytes
Reactive Oxygen Species
Macrophages
Breast Neoplasms

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology
  • Microbiology (medical)

Cite this

Okawa, Y., Murata, Y., Kobayashi, M., Suzuki, M., & Suzuki, S. (1992). Augmentation of host resistance to Candida albicans infection in ascites tumor-bearing mice. Microbiology and Immunology, 36(5), 517-521.

Augmentation of host resistance to Candida albicans infection in ascites tumor-bearing mice. / Okawa, Y.; Murata, Y.; Kobayashi, Makiko; Suzuki, M.; Suzuki, S.

In: Microbiology and Immunology, Vol. 36, No. 5, 1992, p. 517-521.

Research output: Contribution to journalArticle

Okawa, Y, Murata, Y, Kobayashi, M, Suzuki, M & Suzuki, S 1992, 'Augmentation of host resistance to Candida albicans infection in ascites tumor-bearing mice', Microbiology and Immunology, vol. 36, no. 5, pp. 517-521.
Okawa, Y. ; Murata, Y. ; Kobayashi, Makiko ; Suzuki, M. ; Suzuki, S. / Augmentation of host resistance to Candida albicans infection in ascites tumor-bearing mice. In: Microbiology and Immunology. 1992 ; Vol. 36, No. 5. pp. 517-521.
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