Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor-Bearing Mice

Yoshio Okawa, Yoshiko Murata, Makiko Kobayashi, Masuko Suzuki, Shigeo Suzuki

Research output: Contribution to journalArticle

Abstract

We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.

Original languageEnglish (US)
Pages (from-to)575-581
Number of pages7
JournalMicrobiology and Immunology
Volume36
Issue number5
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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    Okawa, Y., Murata, Y., Kobayashi, M., Suzuki, M., & Suzuki, S. (1992). Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor-Bearing Mice. Microbiology and Immunology, 36(5), 575-581.