Abstract
We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 575-581 |
| Number of pages | 7 |
| Journal | Microbiology and Immunology |
| Volume | 36 |
| Issue number | 5 |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology
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Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor-Bearing Mice. / Okawa, Yoshio; Murata, Yoshiko; Kobayashi, Makiko; Suzuki, Masuko; Suzuki, Shigeo.
In: Microbiology and Immunology, Vol. 36, No. 5, 1992, p. 575-581.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor-Bearing Mice
AU - Okawa, Yoshio
AU - Murata, Yoshiko
AU - Kobayashi, Makiko
AU - Suzuki, Masuko
AU - Suzuki, Shigeo
PY - 1992
Y1 - 1992
N2 - We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.
AB - We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=85009569259&partnerID=8YFLogxK
M3 - Article
VL - 36
SP - 575
EP - 581
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 5
ER -