Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression

Sunil K. Chauhan, Jaafar El-Annan, Tatiana Ecoiffier, Sunali Goyal, Qiang Zhang, Daniel R. Saban, Reza Dana

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface, degrades visual performance and the quality of life of >10 million people in the United States alone. The primary limitation in the effective treatment of DED is an incomplete understanding of its specific cellular and molecular pathogenic elements. Using a validated mouse model of DED, herein we functionally characterize the different T cell subsets, including regulatory T cells (Tregs) and pathogenic effector T cells, and determine their contribution to the pathogenesis of DED. Our data demonstrate the presence of dysfunctional Tregs and the resistance of pathogenic T cells, particularly Th17 cells, to Treg suppression in DED. In addition, we clearly show that in vivo blockade of IL-17 significantly reduces the severity and progression of disease, which is paralleled by a reduction in the expansion of Th17 cells and restoration of Treg function. Our findings elucidate involvement of a previously unknown pathogenic T cell subset (Th17) in DED that is associated specifically with Treg dysfunction and disease pathogenesis and suggest a new target for dry eye therapy.

Original languageEnglish (US)
Pages (from-to)1247-1252
Number of pages6
JournalJournal of Immunology
Volume182
Issue number3
StatePublished - Feb 1 2009
Externally publishedYes

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Eye Diseases
Autoimmunity
Th17 Cells
T-Lymphocyte Subsets
T-Lymphocytes
Interleukin-17
Regulatory T-Lymphocytes
Disease Progression
Quality of Life

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Chauhan, S. K., El-Annan, J., Ecoiffier, T., Goyal, S., Zhang, Q., Saban, D. R., & Dana, R. (2009). Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. Journal of Immunology, 182(3), 1247-1252.

Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. / Chauhan, Sunil K.; El-Annan, Jaafar; Ecoiffier, Tatiana; Goyal, Sunali; Zhang, Qiang; Saban, Daniel R.; Dana, Reza.

In: Journal of Immunology, Vol. 182, No. 3, 01.02.2009, p. 1247-1252.

Research output: Contribution to journalArticle

Chauhan, SK, El-Annan, J, Ecoiffier, T, Goyal, S, Zhang, Q, Saban, DR & Dana, R 2009, 'Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression', Journal of Immunology, vol. 182, no. 3, pp. 1247-1252.
Chauhan SK, El-Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR et al. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. Journal of Immunology. 2009 Feb 1;182(3):1247-1252.
Chauhan, Sunil K. ; El-Annan, Jaafar ; Ecoiffier, Tatiana ; Goyal, Sunali ; Zhang, Qiang ; Saban, Daniel R. ; Dana, Reza. / Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. In: Journal of Immunology. 2009 ; Vol. 182, No. 3. pp. 1247-1252.
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