Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression

Sunil K. Chauhan, Jaafar El Annan, Tatiana Ecoiffier, Sunali Goyal, Qiang Zhang, Daniel R. Saban, Reza Dana

Research output: Contribution to journalArticle

176 Scopus citations

Abstract

Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface, degrades visual performance and the quality of life of >10 million people in the United States alone. The primary limitation in the effective treatment of DED is an incomplete understanding of its specific cellular and molecular pathogenic elements. Using a validated mouse model of DED, herein we functionally characterize the different T cell subsets, including regulatory T cells (Tregs) and pathogenic effector T cells, and determine their contribution to the pathogenesis of DED. Our data demonstrate the presence of dysfunctional Tregs and the resistance of pathogenic T cells, particularly Th17 cells, to Treg suppression in DED. In addition, we clearly show that in vivo blockade of IL-17 significantly reduces the severity and progression of disease, which is paralleled by a reduction in the expansion of Th17 cells and restoration of Treg function. Our findings elucidate involvement of a previously unknown pathogenic T cell subset (Th17) in DED that is associated specifically with Treg dysfunction and disease pathogenesis and suggest a new target for dry eye therapy.

Original languageEnglish (US)
Pages (from-to)1247-1252
Number of pages6
JournalJournal of Immunology
Volume182
Issue number3
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Chauhan, S. K., El Annan, J., Ecoiffier, T., Goyal, S., Zhang, Q., Saban, D. R., & Dana, R. (2009). Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. Journal of Immunology, 182(3), 1247-1252. https://doi.org/10.4049/jimmunol.182.3.1247