Automatic control of arterial pressure for hypotensive patients using phenylephrine

Taoufik Wassar, Tamás Luspay, Kallu R. Upendar, Marc Moisi, Richard B. Voigt, Nicole R. Marques, Muzna Khan, Karolos M. Grigoriadis, Matthew A. Franchek, George Kramer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Developed in this paper is an automated closed-loop system that regulates the target blood pressure and maintains haemodynamic stability in hypotensive patients using the vasopressor drug phenylephrine. First, experimental studies are conducted on several healthy swine to identify dynamic mathematical models that quantify and predict blood pressure response to infusion of vasopressors. A firstorder plus time-delay model structure has been selected to capture mean arterial pressure (MAP) response of patient's subject to drug injection. Intra- and inter-patient variabilities of the model parameters have been identified and characterized. Then, an antiwindup proportional integral controller is designed, taking patient response variation in account. A nonlinear stochastic simulation environment has been developed to investigate the controller under diverse scenarios. Finally, automatic control of blood pressure is applied for the treatment of eight anesthetized swine subjected to hypotension induced by standard haemorrhage, spinal cord injury, and vasodilator injection. Results from clinical evaluations show that the proposed automated closed-loop control system is able to keep MAP near target and its performance is superior to that of manual control of infusion.

Original languageEnglish (US)
Pages (from-to)187-198
Number of pages12
JournalInternational Journal of Modelling and Simulation
Volume34
Issue number4
DOIs
StatePublished - Dec 24 2014

Fingerprint

Automatic Control
Blood pressure
Blood Pressure
Closed-loop System
Injection
Drugs
Controller
Manual control
Closed loop control systems
Controllers
Target
Closed-loop Control
Hemodynamics
Stochastic Simulation
Simulation Environment
Model structures
Closed loop systems
Experimental Study
Time Delay
Time delay

Keywords

  • Anti-windup PI controller
  • Blood pressure dynamic modelling
  • Closed-loop drug delivery
  • Hypotensive patient

ASJC Scopus subject areas

  • Hardware and Architecture
  • Software
  • Modeling and Simulation
  • Mechanics of Materials
  • Electrical and Electronic Engineering

Cite this

Automatic control of arterial pressure for hypotensive patients using phenylephrine. / Wassar, Taoufik; Luspay, Tamás; Upendar, Kallu R.; Moisi, Marc; Voigt, Richard B.; Marques, Nicole R.; Khan, Muzna; Grigoriadis, Karolos M.; Franchek, Matthew A.; Kramer, George.

In: International Journal of Modelling and Simulation, Vol. 34, No. 4, 24.12.2014, p. 187-198.

Research output: Contribution to journalArticle

Wassar, T, Luspay, T, Upendar, KR, Moisi, M, Voigt, RB, Marques, NR, Khan, M, Grigoriadis, KM, Franchek, MA & Kramer, G 2014, 'Automatic control of arterial pressure for hypotensive patients using phenylephrine', International Journal of Modelling and Simulation, vol. 34, no. 4, pp. 187-198. https://doi.org/10.2316/Journal.205.2014.4.205-6087
Wassar, Taoufik ; Luspay, Tamás ; Upendar, Kallu R. ; Moisi, Marc ; Voigt, Richard B. ; Marques, Nicole R. ; Khan, Muzna ; Grigoriadis, Karolos M. ; Franchek, Matthew A. ; Kramer, George. / Automatic control of arterial pressure for hypotensive patients using phenylephrine. In: International Journal of Modelling and Simulation. 2014 ; Vol. 34, No. 4. pp. 187-198.
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