@article{96d0ee3ae33e405d86dc4c9c96d516bd,
title = "Autophagy-lysosomal pathway as potential therapeutic target in Parkinson{\textquoteright}s disease",
abstract = "Cellular quality control systems have gained much attention in recent decades. Among these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic cellular components and acts as an anti-ageing process. It is vital for cell survival and to preserve homeostasis. Several cell-type-dependent canonical or non-canonical autophagy pathways have been reported showing varying degrees of selectivity with regard to the substrates targeted. Here, we provide an updated review of the autophagy machinery and discuss the role of various forms of autophagy in neurodegenerative diseases, with a particular focus on Parkinson{\textquoteright}s disease. We describe recent findings that have led to the proposal of therapeutic strategies targeting autophagy to alter the course of Parkinson{\textquoteright}s disease progression.",
keywords = "Autoimmunity, Autophagy, Lysosomes, Neurodegenerative disease, Parkinson{\textquoteright}s disease",
author = "Bonam, {Srinivasa Reddy} and Christine Tranchant and Sylviane Muller",
note = "Funding Information: Acknowledgments: We are grateful to B{\'e}atrice Lannes for providing the images shown in Figure 1. We address our sincere apologies to authors whose work we could not cite due to space limitations. This research was funded in part by the French National Centre for Scientific Research (CNRS), R{\'e}gion Grand-Est, the University of Strasbourg Institute for Advanced Study (USIAS) and the Interdisciplinary Thematic Institute 2021–2028 program of the University of Strasbourg, CNRS and Inserm (ANR-10-IDEX-0002 and ANR-20-SFRI-0012) in the context of the Strasbourg drug discovery and development Institute (IMS). SRB is grateful to Jagadeesh Bayry (INSERM, Centre de Recherche des Cordeliers, Sorbonne Universit{\'e}s, Universit{\'e} de Paris, France and IIT Palakkad, Palakkad, Ker-ala, India) for providing a post-doctoral position. S.M. also acknowledges the support of the TRANSAUTOPHAGY COST Action (CA15138), the French-language autophagy club (CFATG), and the European Regional Development Fund of the European Union in the context of the INTER-REG V Upper Rhine program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 by the author. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = dec,
doi = "10.3390/cells10123547",
language = "English (US)",
volume = "10",
journal = "Cells",
issn = "2073-4409",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "12",
}