B to A transition of DNA on the nanosecond time scale

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90 Scopus citations

Abstract

A 3.5-ns atomic-level computer simulation of a DNA solution was performed. We found that a dodecamer of DNA, which contains the recognition site for Eco RI endonuclease, transforms from B-form to A-form in 0.45 M salt water. This supports an earlier proposal on the A-DNA binding site for transcription factor III.

Original languageEnglish (US)
Pages (from-to)2564-2566
Number of pages3
JournalJournal of physical chemistry
Volume100
Issue number7
DOIs
StatePublished - Feb 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)
  • Physical and Theoretical Chemistry

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