Backs against the wall: Novel and existing strategies used during the 2014-2015 Ebola virus outbreak

Gary Wong, Gary P. Kobinger

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The 2014-2015 outbreak of Ebola virus (EBOV), originating from Guinea, is now responsible for the infection of > 20,000 people in 9 countries. Whereas past filovirus outbreaks in sub-Saharan Africa have been rapidly brought under control with comparably few cases, this outbreak has been particularly resistant to containment efforts. Both the general population and primary health care workers have been affected by this outbreak, with hundreds of doctors and nurses being infected in the line of duty. In the absence of approved therapeutics, several caregivers have turned to investigational new drugs as well as experimental therapies in an effort to save lives. This review aims to summarize the candidates currently under consideration for postexposure use in infected patients during the largest EBOV outbreak in history.

Original languageEnglish (US)
Pages (from-to)593-601
Number of pages9
JournalClinical Microbiology Reviews
Volume28
Issue number3
DOIs
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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