Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels

Csaba Fekete; Sumit Sarkar; Marcelo A. Christoffolete; Charles H. Emerson; Antonio C. Bianco; Ronald M. Lechan

doi:10.1016/j.brainres.2005.07.021

Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels

Csaba Fekete, Sumit Sarkar, Marcelo A. Christoffolete, Charles H. Emerson, Antonio C. Bianco, Ronald M. Lechan

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

By administration of bacterial lipopolysaccharide (LPS) to intact and T4-replaced thyroidectomized rats, we demonstrate that in contrast to the cortex and anterior pituitary, there is a persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal hypothalamus (MBH). We propose that endotoxin-induced D2 activation in the MBH is independent of circulating levels of thyroid hormone and that this mechanism may contribute to central hypothyroidism associated with infection.

Original language	English (US)
Pages (from-to)	97-99
Number of pages	3
Journal	Brain Research
Volume	1056
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2005.07.021
State	Published - Sep 14 2005
Externally published	Yes

Keywords

Bacterial lipopolysaccharide (LPS)
Hypothalic-pituitary-thyroid axis
Infection
Tanycyte
Type 2 iodothyronine deiodinase (D2)

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2005.07.021

Cite this

Fekete, C., Sarkar, S., Christoffolete, M. A., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2005). Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Research, 1056(1), 97-99. https://doi.org/10.1016/j.brainres.2005.07.021

Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. / Fekete, Csaba; Sarkar, Sumit; Christoffolete, Marcelo A. et al.
In: Brain Research, Vol. 1056, No. 1, 14.09.2005, p. 97-99.

Research output: Contribution to journal › Article › peer-review

Fekete, C, Sarkar, S, Christoffolete, MA, Emerson, CH, Bianco, AC & Lechan, RM 2005, 'Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels', Brain Research, vol. 1056, no. 1, pp. 97-99. https://doi.org/10.1016/j.brainres.2005.07.021

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abstract = "By administration of bacterial lipopolysaccharide (LPS) to intact and T4-replaced thyroidectomized rats, we demonstrate that in contrast to the cortex and anterior pituitary, there is a persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal hypothalamus (MBH). We propose that endotoxin-induced D2 activation in the MBH is independent of circulating levels of thyroid hormone and that this mechanism may contribute to central hypothyroidism associated with infection.",

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AU - Sarkar, Sumit

AU - Christoffolete, Marcelo A.

AU - Emerson, Charles H.

AU - Bianco, Antonio C.

AU - Lechan, Ronald M.

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KW - Hypothalic-pituitary-thyroid axis

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Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels

Abstract

Keywords

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