Translocación bacteriana en un modelo de obstrucción intestinal. II. Estudio bacteriológico y papel de la inmunidad celular.

Translated title of the contribution: Bacterial translocation in a model of intestinal obstruction. II. Bacteriological study and role of cellular immunity

Ramon Zapata Sirvent, V. Marzullo Mónaco, S. Piñate, P. del Médico, A. Urbina, A. Larocca, R. Antequera, M. Guzmán, E. Pifano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bacterial translocation (Bt) from the gastrointestinal (GI) tract to systemic organs creates the possibility of Infection and sepsis in a great number of pathologic entities. In a mouse model of Intestinal Obstruction (IO), we evaluated the type of micro-organisms and the organs that bacteria frequent translocated. At 24 hours post-10, positive cultures where obtained at the MLN, portal, systemic circulation and peritoneal cavity, establishing that the translocation is bi-directional. The more frequent bacteria isolated were the Streptococcus group D, Proteus mirabilis, Escherichia coli, Pseudomonas sp., an clostridium. BT occurs at 24 hour post-OI and was due to increased intestinal permeability, at 48 hrs BT increased and related to the physical disruption of the mucosal barrier in the intestinal mucosa. Cell mediated immunity (CMI) response in this model was not altered, although a progressive decrease was observed at 48 hrs it was not significant, suggesting that the CMI play no role in the pathogenesis of BT. In the Control-Laparotomy group, CMI response was increased significantly at 48 hours, suggesting that a simple laparotomy boost the immune defense response.

Original languageSpanish
Pages (from-to)273-280
Number of pages8
JournalGEN
Volume45
Issue number4
StatePublished - Oct 1 1991
Externally publishedYes

Fingerprint

Bacterial Translocation
Intestinal Obstruction
Cellular Immunity
Laparotomy
Bacteria
Proteus mirabilis
Clostridium
Enterococcus faecalis
Peritoneal Cavity
Intestinal Mucosa
Pseudomonas
Gastrointestinal Tract
Permeability
Sepsis
Escherichia coli
Control Groups
Infection

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Zapata Sirvent, R., Marzullo Mónaco, V., Piñate, S., del Médico, P., Urbina, A., Larocca, A., ... Pifano, E. (1991). Translocación bacteriana en un modelo de obstrucción intestinal. II. Estudio bacteriológico y papel de la inmunidad celular. GEN, 45(4), 273-280.

Translocación bacteriana en un modelo de obstrucción intestinal. II. Estudio bacteriológico y papel de la inmunidad celular. / Zapata Sirvent, Ramon; Marzullo Mónaco, V.; Piñate, S.; del Médico, P.; Urbina, A.; Larocca, A.; Antequera, R.; Guzmán, M.; Pifano, E.

In: GEN, Vol. 45, No. 4, 01.10.1991, p. 273-280.

Research output: Contribution to journalArticle

Zapata Sirvent, R, Marzullo Mónaco, V, Piñate, S, del Médico, P, Urbina, A, Larocca, A, Antequera, R, Guzmán, M & Pifano, E 1991, 'Translocación bacteriana en un modelo de obstrucción intestinal. II. Estudio bacteriológico y papel de la inmunidad celular.', GEN, vol. 45, no. 4, pp. 273-280.
Zapata Sirvent R, Marzullo Mónaco V, Piñate S, del Médico P, Urbina A, Larocca A et al. Translocación bacteriana en un modelo de obstrucción intestinal. II. Estudio bacteriológico y papel de la inmunidad celular. GEN. 1991 Oct 1;45(4):273-280.
Zapata Sirvent, Ramon ; Marzullo Mónaco, V. ; Piñate, S. ; del Médico, P. ; Urbina, A. ; Larocca, A. ; Antequera, R. ; Guzmán, M. ; Pifano, E. / Translocación bacteriana en un modelo de obstrucción intestinal. II. Estudio bacteriológico y papel de la inmunidad celular. In: GEN. 1991 ; Vol. 45, No. 4. pp. 273-280.
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