Barrett's esophagus: What do we need to know?

Nabeeha Mohy-ud-din, Timothy S. Krill, Aun Raza Shah, Ahmed T. Chatila, Shailendra Singh, Mohammad Bilal, Sreeram Parupudi

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Barrett's esophagus (BE) is characterized by a change in the mucosal lining of the distal esophagus whereby the squamous epithelium of the esophagus is replaced by the metaplastic columnar epithelium. It is a pre-malignant lesion associated with esophageal adenocarcinoma. Patients with gastroesophageal reflux disease who have additional risk factors (Caucasian race, male gender, age > 50 years, tobacco use, and central obesity) should undergo an esophagogastroduodenoscopy to screen for Barrett's esophagus. Patients with Barrett's esophagus should undergo endoscopic surveillance every 3–5 years if no dysplasia is found. Patients with Barrett's esophagus who are found to have dysplasia should be treated endoscopically. We present a comprehensive review of the pathophysiology, diagnosis, surveillance and management of Barrett's esophagus.

Original languageEnglish (US)
JournalDisease-a-Month
DOIs
StatePublished - Jan 1 2019

Keywords

  • Barrett's esophagus
  • Dysplasia
  • Esophageal adenocarcinoma
  • Intestinal metaplasia

ASJC Scopus subject areas

  • Medicine(all)

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