Basic Fibroblast Growth Factor Opens Calcium‐Permeable Channels in Quail Mesencephalic Neural Crest Neurons

Carla Distasi, Luca Munaron, Fernanda Laezza, Davide Lovisolo

Research output: Contribution to journalArticle

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Abstract

In order to investigate the action of basic fibroblast growth factor (bFGF) in the nervous system, we have studied the ionic signals elicited by this peptide in cultured quail mesencephalic neural crest neurons using patch‐clamp and cytofluorimetric techniques. In this preparation stimulation with bFGF induced, with a delay of some tens of seconds, an inward cationic current. Single‐channel experiments provided evidence for the activation of a calcium‐permeable channel. In single‐cell cytofluorimetric measurements, a sustained rise in [Ca2+Ii was observed, which was dependent on the presence of external calcium. These events may play a role in the developmental effects of bFGF.

Original languageEnglish (US)
Pages (from-to)516-520
Number of pages5
JournalEuropean Journal of Neuroscience
Volume7
Issue number3
DOIs
StatePublished - Mar 1995
Externally publishedYes

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Keywords

  • calcium influx
  • cytosolic calcium increase
  • neuronal development

ASJC Scopus subject areas

  • Neuroscience(all)

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