The human anaphylactic response is described as a rapid, multisystem reaction to a stimulus that may lead to cardiopulmonary failure and death. Anaphylaxis can be caused by many inciting mechanisms, including antigen-IgE interaction, complement-derived anaphylatoxins, and direct mast cell activation. In most anaphylactic reactions, mast cells appear to be the predominant cellular element; however, other cells and immunologic factors are essential as well. The broad physiologic response is due to numerous chemical mediators, such as histamine, arachidonate metabolites, and other inflammatory cell products.
|Original language||English (US)|
|Number of pages||15|
|Journal||Immunology and Allergy Clinics of North America|
|State||Published - Jan 1 1992|
ASJC Scopus subject areas
- Immunology and Allergy