Basic mechanisms of anaphylaxis and anaphylactoid reactions

A. C. DeJarnatt, J. A. Grant

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The human anaphylactic response is described as a rapid, multisystem reaction to a stimulus that may lead to cardiopulmonary failure and death. Anaphylaxis can be caused by many inciting mechanisms, including antigen-IgE interaction, complement-derived anaphylatoxins, and direct mast cell activation. In most anaphylactic reactions, mast cells appear to be the predominant cellular element; however, other cells and immunologic factors are essential as well. The broad physiologic response is due to numerous chemical mediators, such as histamine, arachidonate metabolites, and other inflammatory cell products.

Original languageEnglish (US)
Pages (from-to)501-515
Number of pages15
JournalImmunology and Allergy Clinics of North America
Issue number3
StatePublished - 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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