Abstract
The human anaphylactic response is described as a rapid, multisystem reaction to a stimulus that may lead to cardiopulmonary failure and death. Anaphylaxis can be caused by many inciting mechanisms, including antigen-IgE interaction, complement-derived anaphylatoxins, and direct mast cell activation. In most anaphylactic reactions, mast cells appear to be the predominant cellular element; however, other cells and immunologic factors are essential as well. The broad physiologic response is due to numerous chemical mediators, such as histamine, arachidonate metabolites, and other inflammatory cell products.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 501-515 |
| Number of pages | 15 |
| Journal | Immunology and Allergy Clinics of North America |
| Volume | 12 |
| Issue number | 3 |
| State | Published - 1992 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology