Bax-an emerging role in ectopic cell death

Eleni Dicou; J. Regino Perez-Polo

doi:10.1016/j.ijdevneu.2009.02.005

Bax-an emerging role in ectopic cell death

Eleni Dicou, J. Regino Perez-Polo

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

During embryonic and early postnatal development the combination of cell proliferation, migration, survival and cell death is intimately regulated. In the mouse embryo, significant numbers of primordial germ cells, the founder cells of the gametes, fail to migrate correctly to the genital ridges early in histogenesis. Studies in Bcl-2 associated X protein null mice (Bax^-/-) have shown that the pro-apoptotic Bax gene is required for the programmed cell death of germ cells left in ectopic locations during and after germ cell migration. Independent studies carried out in the central nervous system of Bax^-/- mice have shown impaired and ectopic neuronal migration in the cerebellum and olfactory bulb during development and in the adult hippocampus. Taken together, these evidences identify Bax as a major mechanism in ectopic cell death and are the subject of this review.

Original language	English (US)
Pages (from-to)	299-304
Number of pages	6
Journal	International Journal of Developmental Neuroscience
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.ijdevneu.2009.02.005
State	Published - Jun 2009

Keywords

Bax
Cell death
Ectopic neurons
Ectopic primordial germ cells

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/j.ijdevneu.2009.02.005

Cite this

@article{e5b278b64d874440b7f7892d714b20a1,

title = "Bax-an emerging role in ectopic cell death",

abstract = "During embryonic and early postnatal development the combination of cell proliferation, migration, survival and cell death is intimately regulated. In the mouse embryo, significant numbers of primordial germ cells, the founder cells of the gametes, fail to migrate correctly to the genital ridges early in histogenesis. Studies in Bcl-2 associated X protein null mice (Bax-/-) have shown that the pro-apoptotic Bax gene is required for the programmed cell death of germ cells left in ectopic locations during and after germ cell migration. Independent studies carried out in the central nervous system of Bax-/- mice have shown impaired and ectopic neuronal migration in the cerebellum and olfactory bulb during development and in the adult hippocampus. Taken together, these evidences identify Bax as a major mechanism in ectopic cell death and are the subject of this review.",

keywords = "Bax, Cell death, Ectopic neurons, Ectopic primordial germ cells",

author = "Eleni Dicou and Perez-Polo, {J. Regino}",

year = "2009",

month = jun,

doi = "10.1016/j.ijdevneu.2009.02.005",

language = "English (US)",

volume = "27",

pages = "299--304",

journal = "International Journal of Developmental Neuroscience",

issn = "0736-5748",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Bax-an emerging role in ectopic cell death

AU - Dicou, Eleni

AU - Perez-Polo, J. Regino

PY - 2009/6

Y1 - 2009/6

N2 - During embryonic and early postnatal development the combination of cell proliferation, migration, survival and cell death is intimately regulated. In the mouse embryo, significant numbers of primordial germ cells, the founder cells of the gametes, fail to migrate correctly to the genital ridges early in histogenesis. Studies in Bcl-2 associated X protein null mice (Bax-/-) have shown that the pro-apoptotic Bax gene is required for the programmed cell death of germ cells left in ectopic locations during and after germ cell migration. Independent studies carried out in the central nervous system of Bax-/- mice have shown impaired and ectopic neuronal migration in the cerebellum and olfactory bulb during development and in the adult hippocampus. Taken together, these evidences identify Bax as a major mechanism in ectopic cell death and are the subject of this review.

AB - During embryonic and early postnatal development the combination of cell proliferation, migration, survival and cell death is intimately regulated. In the mouse embryo, significant numbers of primordial germ cells, the founder cells of the gametes, fail to migrate correctly to the genital ridges early in histogenesis. Studies in Bcl-2 associated X protein null mice (Bax-/-) have shown that the pro-apoptotic Bax gene is required for the programmed cell death of germ cells left in ectopic locations during and after germ cell migration. Independent studies carried out in the central nervous system of Bax-/- mice have shown impaired and ectopic neuronal migration in the cerebellum and olfactory bulb during development and in the adult hippocampus. Taken together, these evidences identify Bax as a major mechanism in ectopic cell death and are the subject of this review.

KW - Bax

KW - Cell death

KW - Ectopic neurons

KW - Ectopic primordial germ cells

UR - http://www.scopus.com/inward/record.url?scp=67349143623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349143623&partnerID=8YFLogxK

U2 - 10.1016/j.ijdevneu.2009.02.005

DO - 10.1016/j.ijdevneu.2009.02.005

M3 - Review article

C2 - 19460623

AN - SCOPUS:67349143623

SN - 0736-5748

VL - 27

SP - 299

EP - 304

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

IS - 4

ER -

Bax-an emerging role in ectopic cell death

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this