Bed rest and immunity

Gerald Sonnenfeld, Hernan Aviles, Janet S. Butel, William T. Shearer, David Niesel, Utpal Pandya, Christopher Allen, Hans D. Ochs, Antoine Blancher, Michel Abbal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Space flight has been shown to result in altered immune responses. The current study was designed to investigate this possibility by using the bed rest model of some space flight conditions. A large number of women are included as subjects in the study. The hypothesis being tested is: 60 days head-down tilt bed rest of humans will affect the immune system and resistance to infection. Blood, urine and saliva samples will be obtained from bed rest subjects prior to, at intervals during, and after completion of 60 days of head-down tilt bed rest. Leukocyte blastogenesis, cytokine production and virus reactivation will be assessed. The ability of the subjects to respond appropriately to immunization with the neoantigen bacteriophage φX-174 will also be determined. Bed rest is being carried out at MEDES, Toulouse France, and the University of Texas Medical Branch, Galveston, TX. The studies to be carried out in France will also allow assessment of the effects of muscle/bone exercise and nutritional countermeasures on the immune system in addition to the effects of bed rest.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalActa Astronautica
Volume60
Issue number4-7 SPEC. ISS.
DOIs
StatePublished - Feb 1 2007

Keywords

  • Antibody responses
  • Bed rest
  • Blastogenesis
  • Cytokines
  • Viral reactivation

ASJC Scopus subject areas

  • Aerospace Engineering

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  • Cite this

    Sonnenfeld, G., Aviles, H., Butel, J. S., Shearer, W. T., Niesel, D., Pandya, U., Allen, C., Ochs, H. D., Blancher, A., & Abbal, M. (2007). Bed rest and immunity. Acta Astronautica, 60(4-7 SPEC. ISS.), 234-236. https://doi.org/10.1016/j.actaastro.2006.08.004