Bed rest and myopathies

Arny A. Ferrando, Douglas Paddon-Jones, Robert R. Wolfe

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: The loss of skeletal muscle with injury or critical illness can be dramatic. This review emphasizes the importance of skeletal muscle as a metabolic reserve. Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ameliorate the loss of skeletal muscle are highlighted. RECENT FINDINGS: The loss of skeletal muscle that occurs with inactivity alone can be prevented by nutritional supplementation with an essential amino acid formula. Bed rest with accompanying hypercortisolemia produces a threefold greater loss of skeletal muscle than bed rest alone. Essential amino acids stimulate muscle anabolism during acute hypercortisolemia; however, their effects during chronic hypercortisolemia must be explored. SUMMARY: Skeletal muscle loss with trauma or critical illness is due in great part to the interaction of bed rest (muscular inactivity) and stress (hypercortisolemia). Younger individuals respond to nutritional and pharmacological interventions during bed rest alone. Given a lower relative lean mass in the elderly and the importance of skeletal muscle as a metabolic reserve during stress, it is understandable that clinical outcomes are worse in older patients. Countermeasures to the loss of skeletal muscle, especially in the stressed patient, must be developed.

Original languageEnglish (US)
Pages (from-to)410-415
Number of pages6
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume9
Issue number4
DOIs
StatePublished - Jul 2006

Fingerprint

Bed Rest
muscular diseases
Muscular Diseases
skeletal muscle
Skeletal Muscle
Essential Amino Acids
essential amino acids
Critical Illness
Physiological Stress
Wounds and Injuries
protein metabolism
long term effects
Pharmacology
Muscles
muscles
metabolism

Keywords

  • Essential amino acids
  • Hypercortisolemia
  • Inactivity
  • Muscle protein
  • Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Bed rest and myopathies. / Ferrando, Arny A.; Paddon-Jones, Douglas; Wolfe, Robert R.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 9, No. 4, 07.2006, p. 410-415.

Research output: Contribution to journalArticle

Ferrando, Arny A. ; Paddon-Jones, Douglas ; Wolfe, Robert R. / Bed rest and myopathies. In: Current Opinion in Clinical Nutrition and Metabolic Care. 2006 ; Vol. 9, No. 4. pp. 410-415.
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