Behavior of Leishmania braziliensis s.l. in golden hamsters: Evolution of the infection under different experimental conditions

B. Travi, J. Rey-Ladino, N. G. Saravia

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Reproducibility of Leishmania braziliensis s.l. metastatic behavior in hamsters was studied for 9 isolates of L. b. panamensis and 2 of L. b. guyanensis with a previous record of metastasis. Also, the influence of corticosteroids and trauma was evaluated. In the corticosteroid-treated group, metastases appeared earlier than in the nontreated group, and localization at the site of trauma was more frequent (4/9) than in the nontreated hamsters (1/5). Nine of the 11 strains (82%) were capable of reproducing metastatic behavior. Studies on dissemination of L. b. panamensis showed that the regional lymph node is invaded as soon as 5 days postinfection, with further nonhematic dissemination to other tissues and organs in less than 4 wk.

Original languageEnglish (US)
Pages (from-to)1059-1062
Number of pages4
JournalJournal of Parasitology
Volume74
Issue number6
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

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